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. 1995 Feb;36(2):183–188. doi: 10.1136/gut.36.2.183

Relation between gastric emptying rate and energy intake in children compared with adults.

B D Maes 1, Y F Ghoos 1, B J Geypens 1, M I Hiele 1, P J Rutgeerts 1
PMCID: PMC1382401  PMID: 7883214

Abstract

Measurement of gastric emptying rate of solids in children is difficult because the available methods are either invasive or induce a substantial radiation burden. In this study the newly developed 13C octanoic acid breath test was used to examine the gastric emptying rate of solids and milk in healthy children and to compare gastric emptying in children and adults. Fifteen healthy children and three groups of nine healthy adults were studied, using three different test meals labelled with 50 mg of 13C octanoic acid: a low caloric pancake (150 kcal), a high caloric pancake (250 kcal), and 210 ml of milk (134 kcal). Breath samples were taken before and at regular intervals after ingestion of the test meal, and analysed by isotope ratio mass spectrometry. The gastric emptying parameters were derived from the 13CO2 excretion curves by non-linear regression analysis. No significant difference was found between children and adults in the emptying rate of the low caloric solid test meal. In children as well as in adults, increasing the energy content of the solid meal resulted in a significantly slower emptying rate. The milk test meal, however, was emptied at a faster rate in adults and at slower rate in children compared with the low caloric solid test meal. Moreover, the emptying rate of milk in children was significantly slower than in adults. In conclusion, a similar gastric emptying rate of solids but a slower emptying of full cream milk was shown in children of school age compared with adults, using the non-radioactive 13C octanoic acid breath test.

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Selected References

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  1. Cuber J. C., Bernard C., Levenez F., Chayvialle J. A. Les lipides, protéines et glucides stimulent la sécrétion de cholécystokinine intestinale chez le porc. Reprod Nutr Dev. 1990;30(2):267–275. [PubMed] [Google Scholar]
  2. Daniel H., Vohwinkel M., Rehner G. Effect of casein and beta-casomorphins on gastrointestinal motility in rats. J Nutr. 1990 Mar;120(3):252–257. doi: 10.1093/jn/120.3.252. [DOI] [PubMed] [Google Scholar]
  3. Franco V. H., Collares E. F., Troncon L. E. Gastric emptying in children. IV. Studies on kwashiorkor and on marasmic kwashiorkor. Arq Gastroenterol. 1986 Jan-Mar;23(1):42–46. [PubMed] [Google Scholar]
  4. Fried M. D., Khoshoo V., Secker D. J., Gilday D. L., Ash J. M., Pencharz P. B. Decrease in gastric emptying time and episodes of regurgitation in children with spastic quadriplegia fed a whey-based formula. J Pediatr. 1992 Apr;120(4 Pt 1):569–572. doi: 10.1016/s0022-3476(10)80003-4. [DOI] [PubMed] [Google Scholar]
  5. Ghoos Y. F., Maes B. D., Geypens B. J., Mys G., Hiele M. I., Rutgeerts P. J., Vantrappen G. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology. 1993 Jun;104(6):1640–1647. doi: 10.1016/0016-5085(93)90640-x. [DOI] [PubMed] [Google Scholar]
  6. Grill B. B., Lange R., Markowitz R., Hillemeier A. C., McCallum R. W., Gryboski J. D. Delayed gastric emptying in children with Crohn's disease. J Clin Gastroenterol. 1985 Jun;7(3):216–226. doi: 10.1097/00004836-198506000-00007. [DOI] [PubMed] [Google Scholar]
  7. Gryboski J. D., Burger J., McCallum R., Lange R. Gastric emptying in childhood inflammatory bowel disease: nutritional and pathologic correlates. Am J Gastroenterol. 1992 Sep;87(9):1148–1153. [PubMed] [Google Scholar]
  8. Haycock G. B., Schwartz G. J., Wisotsky D. H. Geometric method for measuring body surface area: a height-weight formula validated in infants, children, and adults. J Pediatr. 1978 Jul;93(1):62–66. doi: 10.1016/s0022-3476(78)80601-5. [DOI] [PubMed] [Google Scholar]
  9. Kelts D. G., Grand R. J., Shen G., Watkins J. B., Werlin S. L., Boehme C. Nutritional basis of growth failure in children and adolescents with Crohn's disease. Gastroenterology. 1979 Apr;76(4):720–727. [PubMed] [Google Scholar]
  10. Lewis L. D., Williams J. A. Regulation of cholecystokinin secretion by food, hormones, and neural pathways in the rat. Am J Physiol. 1990 Apr;258(4 Pt 1):G512–G518. doi: 10.1152/ajpgi.1990.258.4.G512. [DOI] [PubMed] [Google Scholar]
  11. Maes B. D., Hiele M. I., Geypens B. J., Rutgeerts P. J., Ghoos Y. F., Vantrappen G. Pharmacological modulation of gastric emptying rate of solids as measured by the carbon labelled octanoic acid breath test: influence of erythromycin and propantheline. Gut. 1994 Mar;35(3):333–337. doi: 10.1136/gut.35.3.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Meyer B. M., Werth B. A., Beglinger C., Hildebrand P., Jansen J. B., Zach D., Rovati L. C., Stalder G. A. Role of cholecystokinin in regulation of gastrointestinal motor functions. Lancet. 1989 Jul 1;2(8653):12–15. doi: 10.1016/s0140-6736(89)90255-9. [DOI] [PubMed] [Google Scholar]
  13. Miller M. J., Witherly S. A., Clark D. A. Casein: a milk protein with diverse biologic consequences. Proc Soc Exp Biol Med. 1990 Nov;195(2):143–159. doi: 10.3181/00379727-195-43129. [DOI] [PubMed] [Google Scholar]
  14. Papaila J. G., Wilmot D., Grosfeld J. L., Rescorla F. J., West K. W., Vane D. W. Increased incidence of delayed gastric emptying in children with gastroesophageal reflux. A prospective evaluation. Arch Surg. 1989 Aug;124(8):933–936. doi: 10.1001/archsurg.1989.01410080065010. [DOI] [PubMed] [Google Scholar]
  15. Siegel J. A., Urbain J. L., Adler L. P., Charkes N. D., Maurer A. H., Krevsky B., Knight L. C., Fisher R. S., Malmud L. S. Biphasic nature of gastric emptying. Gut. 1988 Jan;29(1):85–89. doi: 10.1136/gut.29.1.85. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Woolridge M. W., Fisher C. Colic, "overfeeding", and symptoms of lactose malabsorption in the breast-fed baby: a possible artifact of feed management? Lancet. 1988 Aug 13;2(8607):382–384. doi: 10.1016/s0140-6736(88)92847-4. [DOI] [PubMed] [Google Scholar]

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