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. 1995 Mar;36(3):382–384. doi: 10.1136/gut.36.3.382

Analysis of Ha-ras 1 allele frequencies in hereditary non-polyposis colorectal cancer.

P Jeevaratnam 1, P J Browett 1, N S Van de Water 1, J R Jass 1
PMCID: PMC1382450  PMID: 7698697

Abstract

Restriction enzyme digests of genomic DNA show multiple alleles of common, intermediate, and rare frequencies at the minisatellite locus of Ha-ras. It has been suggested that a higher frequency of rare alleles is associated with the presence of colorectal and other types of cancer. This study investigated the distribution of Ha-ras alleles in 40 members of hereditary non-polyposis colorectal carcinoma (HNPCC) families and in 34 cancer free subjects (spouses). There was no difference in rare allele frequency between the cancer group and cancer free group (chi2 = 0.25, not significant).

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Selected References

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