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. 1995 Sep;37(3):394–397. doi: 10.1136/gut.37.3.394

Collagenous colitis in Orebro, Sweden, an epidemiological study 1984-1993.

J Bohr 1, C Tysk 1, S Eriksson 1, G Järnerot 1
PMCID: PMC1382821  PMID: 7590436

Abstract

The incidence and prevalence of collagenous colitis are unknown. An epidemiological study was undertaken between 1984-93. All patients living in the immediate catchment area of Orebro Medical Center Hospital with the diagnosis collagenous colitis were identified. Biopsy specimens classified as unspecific intestinal fibrosis were re-examined to identify cases not correctly diagnosed at first. Medical records were scrutinised and colorectal biopsy specimens re-evaluated. Thirty patients with collagenous colitis were diagnosed during the study period. The female:male ratio was 9:1. The median age at diagnosis was 64 (28-78) years. The prevalence at 31 December 1993, was 15.7/10(5) inhabitants (95% CI; 9.8 to 21.6/10(5)). The mean annual incidence during the period 1984-93 was 1.8/10(5) inhabitants (95% CI; 1.2 to 2.4/10(5)). A peak incidence was found in women 70-79 years old. Collagenous colitis occurs mainly in middle aged women, and the frequency is higher than earlier anticipated. The prevalence and incidence is similar to primary biliary cirrhosis. In women 70-79 years of age, the incidence for collagenous colitis approaches the incidence for ulcerative colitis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bogomoletz W. V. Collagenous, microscopic and lymphocytic colitis. An evolving concept. Virchows Arch. 1994;424(6):573–579. doi: 10.1007/BF00195769. [DOI] [PubMed] [Google Scholar]
  2. Carpenter H. A., Tremaine W. J., Batts K. P., Czaja A. J. Sequential histologic evaluations in collagenous colitis. Correlations with disease behavior and sampling strategy. Dig Dis Sci. 1992 Dec;37(12):1903–1909. doi: 10.1007/BF01308086. [DOI] [PubMed] [Google Scholar]
  3. Giardiello F. M., Lazenby A. J., Yardley J. H., Bias W. B., Johnson J., Alianiello R. G., Bedine M. S., Bayless T. M. Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. Dig Dis Sci. 1992 Apr;37(4):496–499. doi: 10.1007/BF01307569. [DOI] [PubMed] [Google Scholar]
  4. Jessurun J., Yardley J. H., Giardiello F. M., Hamilton S. R., Bayless T. M. Chronic colitis with thickening of the subepithelial collagen layer (collagenous colitis): histopathologic findings in 15 patients. Hum Pathol. 1987 Aug;18(8):839–848. doi: 10.1016/s0046-8177(87)80059-x. [DOI] [PubMed] [Google Scholar]
  5. Langholz E., Munkholm P., Nielsen O. H., Kreiner S., Binder V. Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol. 1991 Dec;26(12):1247–1256. doi: 10.3109/00365529108998621. [DOI] [PubMed] [Google Scholar]
  6. Lazenby A. J., Yardley J. H., Giardiello F. M., Bayless T. M. Pitfalls in the diagnosis of collagenous colitis: experience with 75 cases from a registry of collagenous colitis at the Johns Hopkins Hospital. Hum Pathol. 1990 Sep;21(9):905–910. doi: 10.1016/0046-8177(90)90173-3. [DOI] [PubMed] [Google Scholar]
  7. Lindström C. G. 'Collagenous colitis' with watery diarrhoea--a new entity? Pathol Eur. 1976;11(1):87–89. [PubMed] [Google Scholar]
  8. Löfgren J., Järnerot G., Danielsson D., Hemdal I. Incidence and prevalence of primary biliary cirrhosis in a defined population in Sweden. Scand J Gastroenterol. 1985 Jun;20(5):647–650. doi: 10.3109/00365528509089711. [DOI] [PubMed] [Google Scholar]
  9. Midhagen G., Järnerot G., Kraaz W. Adult coeliac disease within a defined geographic area in Sweden. A study of prevalence and associated diseases. Scand J Gastroenterol. 1988 Oct;23(8):1000–1004. doi: 10.3109/00365528809090160. [DOI] [PubMed] [Google Scholar]
  10. Möhrmann C., Glogner P., Caesar R. Die kollagene Kolitis. Untersuchungen zur Abgrenzung und Häufigkeit eines Syndroms. Med Klin (Munich) 1989 Sep 15;84(9):434–438. [PubMed] [Google Scholar]
  11. Pierrugues R., Bories P., Barnéon G., Bernard N., Michel H. La colite collagène. Réflexions à propos de 40 malades. Gastroenterol Clin Biol. 1989 Oct;13(10):811–815. [PubMed] [Google Scholar]
  12. Sloth H., Bisgaard C., Grove A. Collagenous colitis: a prospective trial of prednisolone in six patients. J Intern Med. 1991 May;229(5):443–446. doi: 10.1111/j.1365-2796.1991.tb00372.x. [DOI] [PubMed] [Google Scholar]
  13. Snook J. Are the inflammatory bowel diseases autoimmune disorders? Gut. 1990 Sep;31(9):961–963. doi: 10.1136/gut.31.9.961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Tanaka M., Mazzoleni G., Riddell R. H. Distribution of collagenous colitis: utility of flexible sigmoidoscopy. Gut. 1992 Jan;33(1):65–70. doi: 10.1136/gut.33.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Tysk C., Järnerot G. Ulcerative proctocolitis in Orebro, Sweden. A retrospective epidemiologic study, 1963-1987. Scand J Gastroenterol. 1992 Nov;27(11):945–950. doi: 10.3109/00365529209000168. [DOI] [PubMed] [Google Scholar]

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