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. 1995 Sep;37(3):402–405. doi: 10.1136/gut.37.3.402

C reactive protein and prealbumin as markers of disease activity in shigellosis.

W A Khan 1, M A Salam 1, M L Bennish 1
PMCID: PMC1382823  PMID: 7590438

Abstract

To evaluate serum C reactive protein (CRP) and prealbumin concentrations as markers of disease activity in shigellosis this study serially measured serum concentrations of CRP and prealbumin in 39 patients infected with Shigella spp, and a comparison group of 10 patients infected with Vibrio cholerae serotype 01. On admission, patients with shigellosis had significantly higher median concentrations of CRP (109 v 5 mg/l; p < 0.01) and significantly lower median concentrations of prealbumin (16 v 23 mg/l; p < 0.01) than did patient with cholera. Among Shigella spp infected patients, CRP concentrations were significantly lower, and prealbumin concentrations significantly higher, on study days 3 and 5 when compared with admission values. Among Shigella spp infected patients, those in whom treatment failed had higher admission CRP concentrations than those in whom treatment was successful (p = 0.142). An admission CRP concentration > or = 110 mg/l had a 70% sensitivity and a 61% specificity in predicting failure of treatment among patients infected with Shigella spp; the predictive value of a positive and negative test was 14% and 96% respectively. In summary, acute shigellosis elicits an acute phase response, the magnitude of which predicts clinical outcome.

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Selected References

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  1. Anand B. S., Malhotra V., Bhattacharya S. K., Datta P., Datta D., Sen D., Bhattacharya M. K., Mukherjee P. P., Pal S. C. Rectal histology in acute bacillary dysentery. Gastroenterology. 1986 Mar;90(3):654–660. doi: 10.1016/0016-5085(86)91120-0. [DOI] [PubMed] [Google Scholar]
  2. BARUA D., SACK B. C-REACTIVE PROTEIN IN CHOLERA: A PRELIMINARY REPORT. Bull Calcutta Sch Trop Med. 1963 Jul;11:86–87. [PubMed] [Google Scholar]
  3. Bennish M. L., Harris J. R., Wojtyniak B. J., Struelens M. Death in shigellosis: incidence and risk factors in hospitalized patients. J Infect Dis. 1990 Mar;161(3):500–506. doi: 10.1093/infdis/161.3.500. [DOI] [PubMed] [Google Scholar]
  4. Bennish M. L., Salam M. A., Khan W. A., Khan A. M. Treatment of shigellosis: III. Comparison of one- or two-dose ciprofloxacin with standard 5-day therapy. A randomized, blinded trial. Ann Intern Med. 1992 Nov 1;117(9):727–734. doi: 10.7326/0003-4819-117-9-727. [DOI] [PubMed] [Google Scholar]
  5. Bennish M., Beem M. O., Ormiste V. C-reactive protein and zeta sedimentation ratio as indicators of bacteremia in pediatric patients. J Pediatr. 1984 May;104(5):729–732. doi: 10.1016/s0022-3476(84)80953-1. [DOI] [PubMed] [Google Scholar]
  6. Black R. E., Brown K. H., Becker S. Effects of diarrhea associated with specific enteropathogens on the growth of children in rural Bangladesh. Pediatrics. 1984 Jun;73(6):799–805. [PubMed] [Google Scholar]
  7. Brose L. Prealbumin as a marker of nutritional status. J Burn Care Rehabil. 1990 Jul-Aug;11(4):372–375. doi: 10.1097/00004630-199007000-00020. [DOI] [PubMed] [Google Scholar]
  8. Buckell N. A., Lennard-Jones J. E., Hernandez M. A., Kohn J., Riches P. G., Wadsworth J. Measurement of serum proteins during attacks of ulcerative colitis as a guide to patient management. Gut. 1979 Jan;20(1):22–27. doi: 10.1136/gut.20.1.22. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Butler T., Dunn D., Dahms B., Islam M. Causes of death and the histopathologic findings in fatal shigellosis. Pediatr Infect Dis J. 1989 Nov;8(11):767–772. doi: 10.1097/00006454-198911000-00008. [DOI] [PubMed] [Google Scholar]
  10. Butler T., Islam M. R., Bardhan P. K. The leukemoid reaction in shigellosis. Am J Dis Child. 1984 Feb;138(2):162–165. doi: 10.1001/archpedi.1984.02140400044010. [DOI] [PubMed] [Google Scholar]
  11. GREENOUGH W. B., 3rd, GORDON R. S., Jr, ROSENBERG I. S., DAVIES B. I., BENENSON A. S. TETRACYCLINE IN THE TREATMENT OF CHOLERA. Lancet. 1964 Feb 15;1(7329):355–357. doi: 10.1016/s0140-6736(64)92099-9. [DOI] [PubMed] [Google Scholar]
  12. Henry F. J., Alam N., Aziz K. M., Rahaman M. M. Dysentery, not watery diarrhoea, is associated with stunting in Bangladeshi children. Hum Nutr Clin Nutr. 1987 Jul;41(4):243–249. [PubMed] [Google Scholar]
  13. Ingenbleek Y., De Visscher M., De Nayer P. Measurement of prealbumin as index of protein-calorie malnutrition. Lancet. 1972 Jul 15;2(7768):106–109. doi: 10.1016/s0140-6736(72)91596-6. [DOI] [PubMed] [Google Scholar]
  14. Kabir I., Butler T., Underwood L. E., Rahman M. M. Effects of a protein-rich diet during convalescence from shigellosis on catch-up growth, serum proteins, and insulin-like growth factor-I. Pediatr Res. 1992 Dec;32(6):689–692. doi: 10.1203/00006450-199212000-00014. [DOI] [PubMed] [Google Scholar]
  15. Kabir I., Malek M. A., Mazumder R. N., Rahman M. M., Mahalanabis D. Rapid catch-up growth of children fed a high-protein diet during convalescence from shigellosis. Am J Clin Nutr. 1993 Mar;57(3):441–445. doi: 10.1093/ajcn/57.3.441. [DOI] [PubMed] [Google Scholar]
  16. Kushner I., Gewurz H., Benson M. D. C-reactive protein and the acute-phase response. J Lab Clin Med. 1981 Jun;97(6):739–749. [PubMed] [Google Scholar]
  17. Mathan M. M., Mathan V. I. Ultrastructural pathology of the rectal mucosa in Shigella dysentery. Am J Pathol. 1986 Apr;123(1):25–38. [PMC free article] [PubMed] [Google Scholar]
  18. Shetty P. S., Watrasiewicz K. E., Jung R. T., James W. P. Rapid-turnover transport proteins: an index of subclinical protein-energy malnutrition. Lancet. 1979 Aug 4;2(8136):230–232. doi: 10.1016/s0140-6736(79)90241-1. [DOI] [PubMed] [Google Scholar]
  19. Speelman P., Kabir I., Islam M. Distribution and spread of colonic lesions in shigellosis: a colonoscopic study. J Infect Dis. 1984 Dec;150(6):899–903. doi: 10.1093/infdis/150.6.899. [DOI] [PubMed] [Google Scholar]

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