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. 1995 Oct;37(4):471–476. doi: 10.1136/gut.37.4.471

Lymphocytic gastritis and Helicobacter pylori infection in gastric lymphoma.

A Miettinen 1, T J Karttunen 1, M Alavaikko 1
PMCID: PMC1382895  PMID: 7489930

Abstract

Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. The cases of primary gastric lymphomas (n = 35) diagnosed in years 1970-1993 were identified. The specimens of 22 cases contained gastric mucosa sufficiently so that the number of intra-epithelial lymphocytes, severity of gastritis, and occurrence of H pylori could be studied. Lymphocytic gastritis was detected in seven of 22 patients (32%), and in most cases both in antral and body mucosa. Atrophy of the body glands was significantly more severe in lymphocytic gastritis patients. H pylori was detected in 13 of all 22 patients (59%); two of seven lymphocytic gastritis patients (29%), and 11 of 15 (73%) of patients without lymphocytic gastritis were H pylori positive. Patients with gastric lymphoma have significantly increased prevalence of lymphocytic gastritis. Rarity of H pylori in these patients might be connected with atrophic changes in body mucosa. Further studies are needed to show the significance of lymphocytic gastritis as a precursor of gastric lymphoma.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brandtzaeg P., Halstensen T. S., Kett K., Krajci P., Kvale D., Rognum T. O., Scott H., Sollid L. M. Immunobiology and immunopathology of human gut mucosa: humoral immunity and intraepithelial lymphocytes. Gastroenterology. 1989 Dec;97(6):1562–1584. doi: 10.1016/0016-5085(89)90406-x. [DOI] [PubMed] [Google Scholar]
  2. Carbone P. P., Kaplan H. S., Musshoff K., Smithers D. W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed] [Google Scholar]
  3. Connors J., Wise L. Management of gastric lymphomas. Am J Surg. 1974 Jan;127(1):102–108. doi: 10.1016/0002-9610(74)90018-x. [DOI] [PubMed] [Google Scholar]
  4. Dixon M. F., Wyatt J. I., Burke D. A., Rathbone B. J. Lymphocytic gastritis--relationship to Campylobacter pylori infection. J Pathol. 1988 Feb;154(2):125–132. doi: 10.1002/path.1711540204. [DOI] [PubMed] [Google Scholar]
  5. Doglioni C., Wotherspoon A. C., Moschini A., de Boni M., Isaacson P. G. High incidence of primary gastric lymphoma in northeastern Italy. Lancet. 1992 Apr 4;339(8797):834–835. doi: 10.1016/0140-6736(92)90280-g. [DOI] [PubMed] [Google Scholar]
  6. Engstrand L., Scheynius A., Påhlson C. An increased number of gamma/delta T-cells and gastric epithelial cell expression of the groEL stress-protein homologue in Helicobacter pylori-associated chronic gastritis of the antrum. Am J Gastroenterol. 1991 Aug;86(8):976–980. [PubMed] [Google Scholar]
  7. Fend F., Schwaiger A., Weyrer K., Propst A., Mairinger T., Umlauft F., Judmaier G., Grünewald K. Early diagnosis of gastric lymphoma: gene rearrangement analysis of endoscopic biopsy samples. Leukemia. 1994 Jan;8(1):35–39. [PubMed] [Google Scholar]
  8. Haot J., Bogomoletz W. V., Jouret A., Mainguet P. Ménétrier's disease with lymphocytic gastritis: an unusual association with possible pathogenic implications. Hum Pathol. 1991 Apr;22(4):379–386. doi: 10.1016/0046-8177(91)90086-5. [DOI] [PubMed] [Google Scholar]
  9. Haot J., Hamichi L., Wallez L., Mainguet P. Lymphocytic gastritis: a newly described entity: a retrospective endoscopic and histological study. Gut. 1988 Sep;29(9):1258–1264. doi: 10.1136/gut.29.9.1258. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Haot J., Jouret A., Willette M., Gossuin A., Mainguet P. Lymphocytic gastritis--prospective study of its relationship with varioliform gastritis. Gut. 1990 Mar;31(3):282–285. doi: 10.1136/gut.31.3.282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hayes J., Dunn E. Has the incidence of primary gastric lymphoma increased? Cancer. 1989 May 15;63(10):2073–2076. doi: 10.1002/1097-0142(19890515)63:10<2073::aid-cncr2820631033>3.0.co;2-n. [DOI] [PubMed] [Google Scholar]
  12. Hertzer N. R., Hoerr S. O. An interpretive review of lymphoma of the stomach. Surg Gynecol Obstet. 1976 Jul;143(1):113–124. [PubMed] [Google Scholar]
  13. Hyjek E., Isaacson P. G. Primary B cell lymphoma of the thyroid and its relationship to Hashimoto's thyroiditis. Hum Pathol. 1988 Nov;19(11):1315–1326. doi: 10.1016/s0046-8177(88)80287-9. [DOI] [PubMed] [Google Scholar]
  14. Hyjek E., Smith W. J., Isaacson P. G. Primary B-cell lymphoma of salivary glands and its relationship to myoepithelial sialadenitis. Hum Pathol. 1988 Jul;19(7):766–776. doi: 10.1016/s0046-8177(88)80259-4. [DOI] [PubMed] [Google Scholar]
  15. Isaacson P. G. Lymphomas of mucosa-associated lymphoid tissue (MALT). Histopathology. 1990 Jun;16(6):617–619. doi: 10.1111/j.1365-2559.1990.tb01173.x. [DOI] [PubMed] [Google Scholar]
  16. Isaacson P. G., Spencer J. Malignant lymphoma and autoimmune disease. Histopathology. 1993 May;22(5):509–510. doi: 10.1111/j.1365-2559.1993.tb00169.x. [DOI] [PubMed] [Google Scholar]
  17. Isaacson P. G., Spencer J., Wright D. H. Classifying primary gut lymphomas. Lancet. 1988 Nov 12;2(8620):1148–1149. doi: 10.1016/s0140-6736(88)90574-0. [DOI] [PubMed] [Google Scholar]
  18. Isaacson P., Wright D. H. Extranodal malignant lymphoma arising from mucosa-associated lymphoid tissue. Cancer. 1984 Jun 1;53(11):2515–2524. doi: 10.1002/1097-0142(19840601)53:11<2515::aid-cncr2820531125>3.0.co;2-c. [DOI] [PubMed] [Google Scholar]
  19. Jaser N., Sivula A., Franssila K. Primary gastric non-Hodgkin's lymphoma in Finland, 1972-1977. Clinical presentation and results of treatment. Scand J Gastroenterol. 1990 Oct;25(10):1052–1059. doi: 10.3109/00365529008997634. [DOI] [PubMed] [Google Scholar]
  20. Jaskiewicz K., Price S. K., Zak J., Louwrens H. D. Lymphocytic gastritis in nonulcer dyspepsia. Dig Dis Sci. 1991 Aug;36(8):1079–1083. doi: 10.1007/BF01297450. [DOI] [PubMed] [Google Scholar]
  21. Jones R. E., Willis S., Innes D. J., Wanebo H. J. Primary gastric lymphoma. Problems in staging and management. Am J Surg. 1988 Jan;155(1):118–123. doi: 10.1016/s0002-9610(88)80268-x. [DOI] [PubMed] [Google Scholar]
  22. Karnes W. E., Jr, Samloff I. M., Siurala M., Kekki M., Sipponen P., Kim S. W., Walsh J. H. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology. 1991 Jul;101(1):167–174. doi: 10.1016/0016-5085(91)90474-y. [DOI] [PubMed] [Google Scholar]
  23. Karttunen T., Niemelä S. Lymphocytic gastritis and coeliac disease. J Clin Pathol. 1990 May;43(5):436–437. doi: 10.1136/jcp.43.5.436. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Lim F. E., Hartman A. S., Tan E. G., Cady B., Meissner W. A. Factors in the prognosis of gastric lymphoma. Cancer. 1977 Apr;39(4):1715–1720. doi: 10.1002/1097-0142(197704)39:4<1715::aid-cncr2820390449>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  25. Macon W. R., Williams M. E., Greer J. P., Stein R. S., Collins R. D., Cousar J. B. T-cell-rich B-cell lymphomas. A clinicopathologic study of 19 cases. Am J Surg Pathol. 1992 Apr;16(4):351–363. [PubMed] [Google Scholar]
  26. Marshall B. J., Warren J. R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984 Jun 16;1(8390):1311–1315. doi: 10.1016/s0140-6736(84)91816-6. [DOI] [PubMed] [Google Scholar]
  27. Musshoff K. Klinische Stadieneinteilung der Nicht-Hodgkin-Lymphome. Strahlentherapie. 1977 Apr;153(4):218–221. [PubMed] [Google Scholar]
  28. Price A. B. The Sydney System: histological division. J Gastroenterol Hepatol. 1991 May-Jun;6(3):209–222. doi: 10.1111/j.1440-1746.1991.tb01468.x. [DOI] [PubMed] [Google Scholar]
  29. Radaszkiewicz T., Dragosics B., Bauer P. Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis. Gastroenterology. 1992 May;102(5):1628–1638. doi: 10.1016/0016-5085(92)91723-h. [DOI] [PubMed] [Google Scholar]
  30. Rubio C. A., Kato Y., Sugano H. The lymphoepithelial phenomenon in the gastric mucosa. Pathol Res Pract. 1985 Dec;180(6):612–614. doi: 10.1016/S0344-0338(85)80038-8. [DOI] [PubMed] [Google Scholar]
  31. Severson R. K., Davis S. Increasing incidence of primary gastric lymphoma. Cancer. 1990 Sep 15;66(6):1283–1287. doi: 10.1002/1097-0142(19900915)66:6<1283::aid-cncr2820660631>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
  32. Sipponen P. Atrophic gastritis as a premalignant condition. Ann Med. 1989 Aug;21(4):287–290. doi: 10.3109/07853898909149209. [DOI] [PubMed] [Google Scholar]
  33. Valnes K., Huitfeldt H. S., Brandtzaeg P. Relation between T cell number and epithelial HLA class II expression quantified by image analysis in normal and inflamed human gastric mucosa. Gut. 1990 Jun;31(6):647–652. doi: 10.1136/gut.31.6.647. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Wotherspoon A. C., Ortiz-Hidalgo C., Falzon M. R., Isaacson P. G. Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma. Lancet. 1991 Nov 9;338(8776):1175–1176. doi: 10.1016/0140-6736(91)92035-z. [DOI] [PubMed] [Google Scholar]

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