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. 1995 Oct;37(4):505–508. doi: 10.1136/gut.37.4.505

Quality of life measurement in patients with oesophageal cancer.

J M Blazeby 1, M H Williams 1, S T Brookes 1, D Alderson 1, J R Farndon 1
PMCID: PMC1382901  PMID: 7489936

Abstract

Quality of life (QOL) measurement may aid decision making in the treatment of patients with oesophageal cancer but must be clinically valid to be useful. This study considered if the European Organisation for Research and Treatment of Cancer QOL questionnaire, the QLQ-C30, showed differing results in two clinically distinct groups of patients with oesophageal cancer and also investigated the correlation between dysphagia grade and various scales of QOL. Patients treated by oesophagectomy reported significantly better physical, emotional, cognitive, and global health scores than those in the palliative treatment group. Patients who received palliative treatment had significantly worse pain, fatigue, appetite loss, constipation, and dysphagia. The correlations between dysphagia grade and each of the QOL scales and items in both groups of patients were poor. This questionnaire differentiates clearly between the two clinically distinct groups of patients, but to be an entirely appropriate indicator of QOL in patients with oesophageal cancer, an additional specific oesophageal module including a dysphagia scale is required.

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Selected References

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  1. Aaronson N. K., Ahmedzai S., Bergman B., Bullinger M., Cull A., Duez N. J., Filiberti A., Flechtner H., Fleishman S. B., de Haes J. C. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993 Mar 3;85(5):365–376. doi: 10.1093/jnci/85.5.365. [DOI] [PubMed] [Google Scholar]
  2. Aaronson N. K., Bullinger M., Ahmedzai S. A modular approach to quality-of-life assessment in cancer clinical trials. Recent Results Cancer Res. 1988;111:231–249. doi: 10.1007/978-3-642-83419-6_27. [DOI] [PubMed] [Google Scholar]
  3. Allen-Mersh T. G. Improving palliation for patients with gastrointestinal cancer. Br J Surg. 1994 Jan;81(1):86–86. doi: 10.1002/bjs.1800810129. [DOI] [PubMed] [Google Scholar]
  4. Araújo C. M., Souhami L., Gil R. A., Carvalho R., Garcia J. A., Froimtchuk M. J., Pinto L. H., Canary P. C. A randomized trial comparing radiation therapy versus concomitant radiation therapy and chemotherapy in carcinoma of the thoracic esophagus. Cancer. 1991 May 1;67(9):2258–2261. doi: 10.1002/1097-0142(19910501)67:9<2258::aid-cncr2820670908>3.0.co;2-g. [DOI] [PubMed] [Google Scholar]
  5. Barr H., Krasner N., Raouf A., Walker R. J. Prospective randomised trial of laser therapy only and laser therapy followed by endoscopic intubation for the palliation of malignant dysphagia. Gut. 1990 Mar;31(3):252–258. doi: 10.1136/gut.31.3.252. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cheng K. K., Day N. E. Oesophageal cancer in Britain. BMJ. 1992 Mar 14;304(6828):711–711. doi: 10.1136/bmj.304.6828.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Coggon D., Inskip H. Is there an epidemic of cancer? BMJ. 1994 Mar 12;308(6930):705–708. doi: 10.1136/bmj.308.6930.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Diamantes T., Mannell A. Oesophageal intubation for advanced oesophageal cancer: the Baragwanath experience 1977-1981. Br J Surg. 1983 Sep;70(9):555–557. doi: 10.1002/bjs.1800700916. [DOI] [PubMed] [Google Scholar]
  9. Earlam R., Cunha-Melo J. R. Oesophageal squamous cell carcinoma: I. A critical review of surgery. Br J Surg. 1980 Jun;67(6):381–390. doi: 10.1002/bjs.1800670602. [DOI] [PubMed] [Google Scholar]
  10. Ellis P., Cunningham D. Management of carcinomas of the upper gastrointestinal tract. BMJ. 1994 Mar 26;308(6932):834–838. doi: 10.1136/bmj.308.6932.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fitzpatrick R., Fletcher A., Gore S., Jones D., Spiegelhalter D., Cox D. Quality of life measures in health care. I: Applications and issues in assessment. BMJ. 1992 Oct 31;305(6861):1074–1077. doi: 10.1136/bmj.305.6861.1074. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Griffin S. M., Robertson C. S. Non-surgical treatment of cancer of the oesophagus. Br J Surg. 1993 Apr;80(4):412–413. doi: 10.1002/bjs.1800800403. [DOI] [PubMed] [Google Scholar]
  13. Karlin D. A., Fisher R. S., Krevsky B. Prolonged survival and effective palliation in patients with squamous cell carcinoma of the esophagus following endoscopic laser therapy. Cancer. 1987 Jun 1;59(11):1969–1972. doi: 10.1002/1097-0142(19870601)59:11<1969::aid-cncr2820591123>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
  14. Kelsen D. P., Bains M., Burt M. Neoadjuvant chemotherapy and surgery of cancer of the esophagus. Semin Surg Oncol. 1990;6(5):268–273. doi: 10.1002/ssu.2980060508. [DOI] [PubMed] [Google Scholar]
  15. Lerut T. E., de Leyn P., Coosemans W., Van Raemdonck D., Cuypers P., Van Cleynenbreughel B. Advanced esophageal carcinoma. World J Surg. 1994 May-Jun;18(3):379–387. doi: 10.1007/BF00316818. [DOI] [PubMed] [Google Scholar]
  16. Loizou L. A., Rampton D., Atkinson M., Robertson C., Bown S. G. A prospective assessment of quality of life after endoscopic intubation and laser therapy for malignant dysphagia. Cancer. 1992 Jul 15;70(2):386–391. doi: 10.1002/1097-0142(19920715)70:2<386::aid-cncr2820700203>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  17. Maunoury V., Brunetaud J. M., Cochelard D., Boniface B., Cortot A., Paris J. C. Endoscopic palliation for inoperable malignant dysphagia: long term follow up. Gut. 1992 Dec;33(12):1602–1607. doi: 10.1136/gut.33.12.1602. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Müller J. M., Erasmi H., Stelzner M., Zieren U., Pichlmaier H. Surgical therapy of oesophageal carcinoma. Br J Surg. 1990 Aug;77(8):845–857. doi: 10.1002/bjs.1800770804. [DOI] [PubMed] [Google Scholar]
  19. O'Reilly S., Forastiere A. New approaches to treating oesophageal cancer. BMJ. 1994 May 14;308(6939):1249–1250. doi: 10.1136/bmj.308.6939.1249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Oliver S. E., Robertson C. S., Logan R. F. Oesophageal cancer: a population-based study of survival after treatment. Br J Surg. 1992 Dec;79(12):1321–1325. doi: 10.1002/bjs.1800791226. [DOI] [PubMed] [Google Scholar]
  21. Orringer M. B., Forastiere A. A., Perez-Tamayo C., Urba S., Takasugi B. J., Bromberg J. Chemotherapy and radiation therapy before transhiatal esophagectomy for esophageal carcinoma. Ann Thorac Surg. 1990 Mar;49(3):348–355. doi: 10.1016/0003-4975(90)90237-z. [DOI] [PubMed] [Google Scholar]
  22. Osoba D., Zee B., Pater J., Warr D., Kaizer L., Latreille J. Psychometric properties and responsiveness of the EORTC quality of Life Questionnaire (QLQ-C30) in patients with breast, ovarian and lung cancer. Qual Life Res. 1994 Oct;3(5):353–364. doi: 10.1007/BF00451727. [DOI] [PubMed] [Google Scholar]
  23. Priestman T. J., Baum M. Evaluation of quality of life in patients receiving treatment for advanced breast cancer. Lancet. 1976 Apr 24;1(7965):899–900. doi: 10.1016/s0140-6736(76)92112-7. [DOI] [PubMed] [Google Scholar]
  24. Ringdal G. I., Ringdal K. Testing the EORTC Quality of Life Questionnaire on cancer patients with heterogeneous diagnoses. Qual Life Res. 1993 Apr;2(2):129–140. doi: 10.1007/BF00435732. [DOI] [PubMed] [Google Scholar]
  25. Sagar P. M., Gauperaa T., Sue-Ling H., McMahon M. J., Johnston D. An audit of the treatment of cancer of the oesophagus. Gut. 1994 Jul;35(7):941–945. doi: 10.1136/gut.35.7.941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Salama F. D., Leong Y. P. Resection for carcinoma of the oesophagus. J R Coll Surg Edinb. 1989 Apr;34(2):97–100. [PubMed] [Google Scholar]
  27. Spitzer W. O., Dobson A. J., Hall J., Chesterman E., Levi J., Shepherd R., Battista R. N., Catchlove B. R. Measuring the quality of life of cancer patients: a concise QL-index for use by physicians. J Chronic Dis. 1981;34(12):585–597. doi: 10.1016/0021-9681(81)90058-8. [DOI] [PubMed] [Google Scholar]
  28. Szawłowski A. W., Falkowski S., Morysiński T., Nasierowska-Guttmejer A., Karwowski A., Krawczyk M., Kułakowski A. Preoperative concurrent chemotherapy and radiotherapy for local-regional and advanced squamous cell carcinoma of the thoracic oesophagus: preliminary results of a pilot study. Eur J Surg Oncol. 1991 Dec;17(6):575–580. [PubMed] [Google Scholar]
  29. Watson A. A study of the quality and duration of survival following resection, endoscopic intubation and surgical intubation in oesophageal carcinoma. Br J Surg. 1982 Oct;69(10):585–588. doi: 10.1002/bjs.1800691009. [DOI] [PubMed] [Google Scholar]
  30. de Haes J. C., van Knippenberg F. C., Neijt J. P. Measuring psychological and physical distress in cancer patients: structure and application of the Rotterdam Symptom Checklist. Br J Cancer. 1990 Dec;62(6):1034–1038. doi: 10.1038/bjc.1990.434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. van Knippenberg F. C., Out J. J., Tilanus H. W., Mud H. J., Hop W. C., Verhage F. Quality of Life in patients with resected oesophageal cancer. Soc Sci Med. 1992 Jul;35(2):139–145. doi: 10.1016/0277-9536(92)90161-i. [DOI] [PubMed] [Google Scholar]

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