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. 1995 Dec;37(6):830–834. doi: 10.1136/gut.37.6.830

Family history of colorectal tumours and implications for the adenoma-carcinoma sequence: a case control study.

M C Boutron 1, J Faivre 1, V Quipourt 1, P Senesse 1, C Michiels 1
PMCID: PMC1382947  PMID: 8537056

Abstract

Family history of colorectal cancer is a risk factor for sporadic colorectal cancer, but it is not known which step of the adenoma-carcinoma pathway it influences. This case control study investigated the relation between family history of cancer and colorectal adenomas and cancers. Family history of colorectal cancer (FHCRC) was as frequent in small (< 10 mm) adenoma patients (11.7%, n = 154) as in polyp free patients (10.6%, n = 426), whereas it was more frequent in patients with large adenoma(s) (18.8%, n = 208; p < 0.01). Odds ratios for FHCRC were 1.2 (p > 0.10) for small adenomas and 2.1 (p < 0.01) for large adenomas. Family history of other (non-colorectal) cancers (FHOC) was similar in the three groups. Patients with a colorectal cancer (n = 171) had more frequently a family history of cancer, both colorectal (15.8%; p < 0.01) and other cancers (35.7%; p < 0.001) than general population controls (n = 309; FHCRC: 8.1%; FHOC: 21.7%). In a logistic model, both factors were independently related to colorectal cancers (odds ratios: 1.9 (p < 0.05) for FHCRC and 2.1 (p < 0.001) for FHOC). These data suggest that family history of colorectal cancer influences only the growth of adenomas or their malignant transformation. The finding of a further predisposition to any type of cancer needs to be confirmed.

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Selected References

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  1. Atkin W. S., Morson B. C., Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med. 1992 Mar 5;326(10):658–662. doi: 10.1056/NEJM199203053261002. [DOI] [PubMed] [Google Scholar]
  2. Bonelli L., Martines H., Conio M., Bruzzi P., Aste H. Family history of colorectal cancer as a risk factor for benign and malignant tumours of the large bowel. A case-control study. Int J Cancer. 1988 Apr 15;41(4):513–517. doi: 10.1002/ijc.2910410407. [DOI] [PubMed] [Google Scholar]
  3. Boutron M. C., Faivre J., Dop M. C., Quipourt V., Senesse P. Tobacco, alcohol, and colorectal tumors: a multistep process. Am J Epidemiol. 1995 Jun 1;141(11):1038–1046. [PubMed] [Google Scholar]
  4. Bruzzi P., Green S. B., Byar D. P., Brinton L. A., Schairer C. Estimating the population attributable risk for multiple risk factors using case-control data. Am J Epidemiol. 1985 Nov;122(5):904–914. doi: 10.1093/oxfordjournals.aje.a114174. [DOI] [PubMed] [Google Scholar]
  5. Burt R. W., Bishop D. T., Cannon L. A., Dowdle M. A., Lee R. G., Skolnick M. H. Dominant inheritance of adenomatous colonic polyps and colorectal cancer. N Engl J Med. 1985 Jun 13;312(24):1540–1544. doi: 10.1056/NEJM198506133122403. [DOI] [PubMed] [Google Scholar]
  6. Cannon-Albright L. A., Skolnick M. H., Bishop D. T., Lee R. G., Burt R. W. Common inheritance of susceptibility to colonic adenomatous polyps and associated colorectal cancers. N Engl J Med. 1988 Sep 1;319(9):533–537. doi: 10.1056/NEJM198809013190902. [DOI] [PubMed] [Google Scholar]
  7. Duncan J. L., Kyle J. Family incidence of carcinoma of the colon and rectum in north-east Scotland. Gut. 1982 Feb;23(2):169–171. doi: 10.1136/gut.23.2.169. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Fearon E. R., Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990 Jun 1;61(5):759–767. doi: 10.1016/0092-8674(90)90186-i. [DOI] [PubMed] [Google Scholar]
  9. Groden J., Thliveris A., Samowitz W., Carlson M., Gelbert L., Albertsen H., Joslyn G., Stevens J., Spirio L., Robertson M. Identification and characterization of the familial adenomatous polyposis coli gene. Cell. 1991 Aug 9;66(3):589–600. doi: 10.1016/0092-8674(81)90021-0. [DOI] [PubMed] [Google Scholar]
  10. Grossman S., Milos M. L., Tekawa I. S., Jewell N. P. Colonoscopic screening of persons with suspected risk factors for colon cancer: II. Past history of colorectal neoplasms. Gastroenterology. 1989 Feb;96(2 Pt 1):299–306. doi: 10.1016/0016-5085(89)91551-5. [DOI] [PubMed] [Google Scholar]
  11. Kadlubar F. F., Butler M. A., Kaderlik K. R., Chou H. C., Lang N. P. Polymorphisms for aromatic amine metabolism in humans: relevance for human carcinogenesis. Environ Health Perspect. 1992 Nov;98:69–74. doi: 10.1289/ehp.929869. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Kune G. A., Kune S., Watson L. F. The role of heredity in the etiology of large bowel cancer: data from the Melbourne Colorectal Cancer Study. World J Surg. 1989 Jan-Feb;13(1):124–131. doi: 10.1007/BF01671173. [DOI] [PubMed] [Google Scholar]
  13. Leach F. S., Nicolaides N. C., Papadopoulos N., Liu B., Jen J., Parsons R., Peltomäki P., Sistonen P., Aaltonen L. A., Nyström-Lahti M. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell. 1993 Dec 17;75(6):1215–1225. doi: 10.1016/0092-8674(93)90330-s. [DOI] [PubMed] [Google Scholar]
  14. Lindblom A., Tannergård P., Werelius B., Nordenskjöld M. Genetic mapping of a second locus predisposing to hereditary non-polyposis colon cancer. Nat Genet. 1993 Nov;5(3):279–282. doi: 10.1038/ng1193-279. [DOI] [PubMed] [Google Scholar]
  15. Lotfi A. M., Spencer R. J., Ilstrup D. M., Melton L. J., 3rd Colorectal polyps and the risk of subsequent carcinoma. Mayo Clin Proc. 1986 May;61(5):337–343. doi: 10.1016/s0025-6196(12)61950-8. [DOI] [PubMed] [Google Scholar]
  16. Lothe R. A., Peltomäki P., Meling G. I., Aaltonen L. A., Nyström-Lahti M., Pylkkänen L., Heimdal K., Andersen T. I., Møller P., Rognum T. O. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res. 1993 Dec 15;53(24):5849–5852. [PubMed] [Google Scholar]
  17. Maire P., Morichau-Beauchant M., Drucker J., Barboteau M. A., Barbier J., Matuchansky C. Prévalence familiale du cancer du côlon et du rectum: résultats d'une enquête "cas-témoins" de 3 ans. Gastroenterol Clin Biol. 1984 Jan;8(1):22–27. [PubMed] [Google Scholar]
  18. Ponz de Leon M., Antonioli A., Ascari A., Zanghieri G., Sacchetti C. Incidence and familial occurrence of colorectal cancer and polyps in a health-care district of northern Italy. Cancer. 1987 Dec 1;60(11):2848–2859. doi: 10.1002/1097-0142(19871201)60:11<2848::aid-cncr2820601141>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  19. Spigelman A. D., Owen R. W., Hill M. J., Phillips R. K. Biliary bile acid profiles in familial adenomatous polyposis. Br J Surg. 1991 Mar;78(3):321–325. doi: 10.1002/bjs.1800780318. [DOI] [PubMed] [Google Scholar]
  20. Stephenson B. M., Finan P. J., Gascoyne J., Garbett F., Murday V. A., Bishop D. T. Frequency of familial colorectal cancer. Br J Surg. 1991 Oct;78(10):1162–1166. doi: 10.1002/bjs.1800781005. [DOI] [PubMed] [Google Scholar]
  21. Young J., Leggett B., Gustafson C., Ward M., Searle J., Thomas L., Buttenshaw R., Chenevix-Trench G. Genomic instability occurs in colorectal carcinomas but not in adenomas. Hum Mutat. 1993;2(5):351–354. doi: 10.1002/humu.1380020505. [DOI] [PubMed] [Google Scholar]

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