Skip to main content
PMC home page
Gut logoLink to Gut
. 1995 Dec;37(6):838–839. doi: 10.1136/gut.37.6.838

Mesalazine induced exacerbation of ulcerative colitis.

K C Kapur 1, G T Williams 1, M C Allison 1
PMCID: PMC1382949  PMID: 8537058

Abstract

5-Aminosalicylic acid (5-ASA) compounds occasionally exacerbate diarrhoea in patients with inflammatory bowel disease. This is thought to be due to a secretory mechanism in most cases. A patient with presumed intolerance to sulphasalazine and 5-ASA preparations who developed endoscopic and histological evidence of disease relapse after a rectal challenge with mesalazine is reported.

Full text

PDF
838

Images in this article

839Figure
on p.839

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Austin C. A., Cann P. A., Jones T. H., Holdsworth C. D. Exacerbation of diarrhoea and pain in patients treated with 5-aminosalicylic acid for ulcerative colitis. Lancet. 1984 Apr 21;1(8382):917–918. doi: 10.1016/s0140-6736(84)91386-2. [DOI] [PubMed] [Google Scholar]
  2. Bjarnason I., Hayllar J., MacPherson A. J., Russell A. S. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans. Gastroenterology. 1993 Jun;104(6):1832–1847. doi: 10.1016/0016-5085(93)90667-2. [DOI] [PubMed] [Google Scholar]
  3. Chakraborty T. K., Bhatia D., Heading R. C., Ford M. J. Salicylate induced exacerbation of ulcerative colitis. Gut. 1987 May;28(5):613–615. doi: 10.1136/gut.28.5.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Fardy J. M., Lloyd D. A., Reynolds R. P. Adverse effects with oral 5-aminosalicyclic acid. J Clin Gastroenterol. 1988 Dec;10(6):635–637. doi: 10.1097/00004836-198812000-00012. [DOI] [PubMed] [Google Scholar]
  5. Giaffer M. H., O'Brien C. J., Holdsworth C. D. Clinical tolerance to three 5-aminosalicylic acid releasing preparations in patients with inflammatory bowel disease intolerant or allergic to sulphasalazine. Aliment Pharmacol Ther. 1992 Feb;6(1):51–59. doi: 10.1111/j.1365-2036.1992.tb00544.x. [DOI] [PubMed] [Google Scholar]
  6. Rampton D. S., McNeil N. I., Sarner M. Analgesic ingestion and other factors preceding relapse in ulcerative colitis. Gut. 1983 Mar;24(3):187–189. doi: 10.1136/gut.24.3.187. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Rampton D. S., Sladen G. E. Relapse of ulcerative proctocolitis during treatment with non-steroidal anti-inflammatory drugs. Postgrad Med J. 1981 May;57(667):297–299. doi: 10.1136/pgmj.57.667.297. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Rao S. S., Cann P. A., Holdsworth C. D. Clinical experience of the tolerance of mesalazine and olsalazine in patients intolerant of sulphasalazine. Scand J Gastroenterol. 1987 Apr;22(3):332–336. doi: 10.3109/00365528709078600. [DOI] [PubMed] [Google Scholar]
  9. Ruppin H., Domschke S. Acute ulcerative colitis--a rare complication of sulfasalazine therapy. Hepatogastroenterology. 1984 Aug;31(4):192–193. [PubMed] [Google Scholar]
  10. Sandberg-Gertzén H., Järnerot G., Kraaz W. Azodisal sodium in the treatment of ulcerative colitis. A study of tolerance and relapse-prevention properties. Gastroenterology. 1986 Apr;90(4):1024–1030. doi: 10.1016/0016-5085(86)90882-6. [DOI] [PubMed] [Google Scholar]
  11. Scheurlen C., Allgayer H., Kruis W., Erdmann E., Sauerbruch T. Effect of olsalazine and mesalazine on human ileal and colonic (Na+ + K+)-ATPase. A possible diarrhogenic factor? Clin Investig. 1993 Apr;71(4):286–289. doi: 10.1007/BF00184728. [DOI] [PubMed] [Google Scholar]
  12. Schwartz A. G., Targan S. R., Saxon A., Weinstein W. M. Sulfasalazine-induced exacerbation of ulcerative colitis. N Engl J Med. 1982 Feb 18;306(7):409–412. doi: 10.1056/NEJM198202183060708. [DOI] [PubMed] [Google Scholar]
  13. Werlin S. L., Grand R. J. Bloody diarrhea--a new complication of sulfasalazine. J Pediatr. 1978 Mar;92(3):450–451. doi: 10.1016/s0022-3476(78)80446-6. [DOI] [PubMed] [Google Scholar]

Articles from Gut are provided here courtesy of BMJ Publishing Group

RESOURCES