Abstract
Ileostomy polyps are uncommon and poorly described. The aim of this study was to undertake a retrospective clinicopathological review of ileostomy polyps. Seven patients with 60 polyps arising on ileostomies performed for ulcerative colitis were studied. The histopathological evaluation of archival ileostomy biopsy specimens, polypectomy or excision specimens, and clinical review of patient records was undertaken. Fifty of 60 polyps were inflammatory cap polyps and six further polyps were composed of granulation tissue only. They occurred anywhere on the stoma at any time after ileostomy construction and were strongly associated with overt stomal prolapse. Four neoplastic polyps were identified in two patients 27-36 years after ileostomy construction; all occurred at the mucocutaneous junction. One patient presented with a 2 cm polypoid invasive adenocarcinoma while in the second a 1.7 cm polypoid mucinous adenocarcinoma and a 0.7 cm ileal tubular adenoma with high grade dysplasia occurred at the site of excision of a cap polyp showing focal low grade adenomatous dysplasia six years previously. Neoplastic and non-neoplastic polyps could not be differentiated clinically. It was found that most ileostomy polyps are inflammatory cap polyps associated with stomal prolapse. Less common are polypoid adenomas or adenocarcinomas arising at the mucocutaneous anastomosis > 20 years after ileostomy construction. To prevent ileostomy carcinoma it is recommended that a biopsy of all polyps at the mucocutaneous anastomosis and of any non-prolapse associated polyps elsewhere on the stoma occurring > 15 years after ileostomy construction is done.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Awad R. W., el-Gohary T. M., Skilton J. S., Elder J. B. Life quality and psychological morbidity with an ileostomy. Br J Surg. 1993 Feb;80(2):252–253. doi: 10.1002/bjs.1800800247. [DOI] [PubMed] [Google Scholar]
- BROWN C. H., DIAZ R. J., MICHENER W. M. CARCINOMA OF THE COLON AND ILEUM IN CHRONIC ULCERATIVE COLITIS WITH REFLUX ILEITIS. REPORT OF A CASE OF A SIXTEEN-YEAR-OLD BOY. Gastroenterology. 1964 Sep;47:306–312. [PubMed] [Google Scholar]
- Blazeby J. M., Durdey P., Warren B. F. Polypoid mucosal prolapse in a pelvic ileal reservoir. Gut. 1994 Nov;35(11):1668–1669. doi: 10.1136/gut.35.11.1668. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Carey P. D., Suvarna S. K., Baloch K. G., Guillou P. J., Monson J. R. Primary adenocarcinoma in an ileostomy: a late complication of surgery for ulcerative colitis. Surgery. 1993 Jun;113(6):712–715. [PubMed] [Google Scholar]
- Chetty R., Bhathal P. S., Slavin J. L. Prolapse-induced inflammatory polyps of the colorectum and anal transitional zone. Histopathology. 1993 Jul;23(1):63–67. doi: 10.1111/j.1365-2559.1993.tb01184.x. [DOI] [PubMed] [Google Scholar]
- Gadacz T. R., McFadden D. W., Gabrielson E. W., Ullah A., Berman J. J. Adenocarcinoma of the ileostomy: the latent risk of cancer after colectomy for ulcerative colitis and familial polyposis. Surgery. 1990 Jun;107(6):698–703. [PubMed] [Google Scholar]
- Gorbach S. L., Nahas L., Weinstein L., Levitan R., Patterson J. F. Studies of intestinal microflora. IV. The microflora of ileostomy effluent: a unique microbial ecology. Gastroenterology. 1967 Dec;53(6):874–880. [PubMed] [Google Scholar]
- Griffiths A. P., Hopkinson J. M., Dixon M. F. Inflammatory myoglandular polyp causing ileo-ileal intussusception. Histopathology. 1993 Dec;23(6):596–598. doi: 10.1111/j.1365-2559.1993.tb01257.x. [DOI] [PubMed] [Google Scholar]
- SPICER S. S. DIAMINE METHODS FOR DIFFERENTIALING MUCOSUBSTANCES HISTOCHEMICALLY. J Histochem Cytochem. 1965 Mar;13:211–234. doi: 10.1177/13.3.211. [DOI] [PubMed] [Google Scholar]
- Saul S. H. Inflammatory cloacogenic polyp: relationship to solitary rectal ulcer syndrome/mucosal prolapse and other bowel disorders. Hum Pathol. 1987 Nov;18(11):1120–1125. doi: 10.1016/s0046-8177(87)80379-9. [DOI] [PubMed] [Google Scholar]
- Schlippert W., Mitros F., Schulze K. Multiple adenocarcinomas and premalignant changes in "backwash" ileitis. Am J Med. 1979 May;66(5):879–882. doi: 10.1016/0002-9343(79)91146-x. [DOI] [PubMed] [Google Scholar]
- Starke J., Rodriguez-Bigas M., Marshall W., Sohrabi A., Petrelli N. J. Primary adenocarcinoma arising in an ileostomy. Surgery. 1993 Jul;114(1):125–128. [PubMed] [Google Scholar]
- Suarez V., Alexander-Williams J., O'Connor H. J., Campos A., Fuggle W. J., Thompson H., Enker W. E., Greenstein A. J. Carcinoma developing in ileostomies after 25 or more years. Gastroenterology. 1988 Jul;95(1):205–208. doi: 10.1016/0016-5085(88)90313-7. [DOI] [PubMed] [Google Scholar]
- Todd I. P. Mechanical complications of ileostomy. Clin Gastroenterol. 1982 May;11(2):268–273. [PubMed] [Google Scholar]