Abstract
Three patients are described in whom renal cell carcinoma was diagnosed between seven months and 14 years after the onset of ulcerative colitis. All three had required treatment with corticosteroids and azathioprine, as well as maintenance therapy with 5-aminosalicylate derivatives, for chronic active colitis. One patient had coexisting polymyalgia rheumatica; one had primary biliary cirrhosis. It is uncertain whether this association, which has not previously been described, has pathogenetic importance or has arisen simply by chance. Genetic predisposition or the effect of drug treatment, particularly immunosuppression, may be pertinent to the co-occurrence of these diseases.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Connell W. R., Kamm M. A., Dickson M., Balkwill A. M., Ritchie J. K., Lennard-Jones J. E. Long-term neoplasia risk after azathioprine treatment in inflammatory bowel disease. Lancet. 1994 May 21;343(8908):1249–1252. doi: 10.1016/s0140-6736(94)92150-4. [DOI] [PubMed] [Google Scholar]
- Dwarakanath A. D., Michael J., Allan R. N. Sulphasalazine induced renal failure. Gut. 1992 Jul;33(7):1006–1007. doi: 10.1136/gut.33.7.1006. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoover R., Fraumeni J. F., Jr Risk of cancer in renal-transplant recipients. Lancet. 1973 Jul 14;2(7820):55–57. doi: 10.1016/s0140-6736(73)93256-x. [DOI] [PubMed] [Google Scholar]
- LaForgia S., Lasota J., Latif F., Boghosian-Sell L., Kastury K., Ohta M., Druck T., Atchison L., Cannizzaro L. A., Barnea G. Detailed genetic and physical map of the 3p chromosome region surrounding the familial renal cell carcinoma chromosome translocation, t(3;8)(p14.2;q24.1). Cancer Res. 1993 Jul 1;53(13):3118–3124. [PubMed] [Google Scholar]
- McLaughlin J. K., Mandel J. S., Blot W. J., Schuman L. M., Mehl E. S., Fraumeni J. F., Jr A population--based case--control study of renal cell carcinoma. J Natl Cancer Inst. 1984 Feb;72(2):275–284. [PubMed] [Google Scholar]
- Mittal B. V., Cotton R. E. Severely atypical changes in renal epithelium in biopsy and graft nephrectomy specimens in two cases of cadaver renal transplantation. Histopathology. 1987 Aug;11(8):833–841. doi: 10.1111/j.1365-2559.1987.tb01886.x. [DOI] [PubMed] [Google Scholar]
- Satsangi J., Jewell D. P., Rosenberg W. M., Bell J. I. Genetics of inflammatory bowel disease. Gut. 1994 May;35(5):696–700. doi: 10.1136/gut.35.5.696. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thuluvath P. J., Ninkovic M., Calam J., Anderson M. Mesalazine induced interstitial nephritis. Gut. 1994 Oct;35(10):1493–1496. doi: 10.1136/gut.35.10.1493. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Yu M. C., Mack T. M., Hanisch R., Cicioni C., Henderson B. E. Cigarette smoking, obesity, diuretic use, and coffee consumption as risk factors for renal cell carcinoma. J Natl Cancer Inst. 1986 Aug;77(2):351–356. [PubMed] [Google Scholar]