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. 1996 Feb;38(2):190–195. doi: 10.1136/gut.38.2.190

T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut.

R Thomas 1, G Schürmann 1, P Lionetti 1, S L Pender 1, T T MacDonald 1
PMCID: PMC1383021  PMID: 8801195

Abstract

A panel of T cell receptor V beta specific monoclonal antibodies was used to analyse V beta gene usage at different sites in human postnatal and fetal intestine. In normal small intestine, at a single site, different patients showed expansion of T cells expressing individual V beta s. Lamina propria and epithelial T cells from the same patient showed overlapping but not identical V beta dominance. V beta dominance was also shown in the T cells of the colonic lamina propria. Analysis of two separate regions of intestine from the same patient (5-100 cm apart) showed that T cells expressing a dominant V beta region were often present at both sites. In most patients, however, major biases in T cell V beta usage (two to 12-fold variation) were also apparent between the two sites. Analysis of V beta expression in human fetal intestine also showed considerable skewing, although the most common dominant V beta in postnatal intestine (V beta 22) was never predominant in fetal intestine. Patchy local variation in the expression of individual V beta s therefore occurs against a background of V beta dominance over large regions of the human gut. Furthermore the results from fetal gut show that factors other than luminal antigen control V beta expression in the gut.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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