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. 1996 Oct;39(4):613–614. doi: 10.1136/gut.39.4.613

Ulceration of the small intestine in children with coeliac disease.

M Eltumi 1, M J Brueton 1, N Francis 1
PMCID: PMC1383279  PMID: 8944575

Abstract

BACKGROUND: Ulceration of the small intestine in children has not been previously described. PATIENTS: Two children, aged 12 and 18 months, presented with a history of failure to thrive and intractable diarrhoea. RESULTS AND CONCLUSIONS: Upper gastrointestinal endoscopy showed multiple ulcers involving the first and second parts of the duodenum. Histology of biopsy specimens taken from these sites confirmed ulceration and showed other features consistent with a diagnosis of coeliac disease. They both showed pronounced clinical improvement and satisfactory linear growth on a gluten free diet. A year later the diagnosis of coeliac disease was confirmed on a biopsy controlled gluten challenge, and repeat endoscopy showed complete resolution of the intestinal ulceration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baer A. N., Bayless T. M., Yardley J. H. Intestinal ulceration and malabsorption syndromes. Gastroenterology. 1980 Oct;79(4):754–765. [PubMed] [Google Scholar]
  2. Bayless T. M., Kapelowitz R. F., Shelley W. M., Ballinger W. F., 2nd, Hendrix T. R. Intestinal ulceration--a complication of celiac disease. N Engl J Med. 1967 May 4;276(18):996–1002. doi: 10.1056/NEJM196705042761802. [DOI] [PubMed] [Google Scholar]
  3. Isaacson P., Wright D. H. Intestinal lymphoma associated with malabsorption. Lancet. 1978 Jan 14;1(8055):67–70. doi: 10.1016/s0140-6736(78)90004-1. [DOI] [PubMed] [Google Scholar]
  4. Jones P. E., Gleeson M. H. Mucosal ulceration and mesenteric lymphadenopathy in coeliac disease. Br Med J. 1973 Jul 28;3(5873):212–213. doi: 10.1136/bmj.3.5873.212. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kiely P. B., O'Donovan P. J., O'Donovan P. A. Benign ulceration, perforation and intussusception in coeliac disease. J R Coll Surg Edinb. 1985 Aug;30(4):272–273. [PubMed] [Google Scholar]
  6. Mills P. R., Brown I. L., Watkinson G. Idiopathic chronic ulcerative enteritis. Report of five cases and review of the literature. Q J Med. 1980 Spring;49(194):133–149. [PubMed] [Google Scholar]
  7. Robertson D. A., Dixon M. F., Scott B. B., Simpson F. G., Losowsky M. S. Small intestinal ulceration: diagnostic difficulties in relation to coeliac disease. Gut. 1983 Jun;24(6):565–574. doi: 10.1136/gut.24.6.565. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Venturatos S. G., Hines C., Jr, Blalock J. B. Ulceration of the small intestine in a patient with celiac disease. South Med J. 1984 Apr;77(4):520–522. doi: 10.1097/00007611-198404000-00030. [DOI] [PubMed] [Google Scholar]

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