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. 1990 May;70(1):136–137.

Expression of genes for interleukin-1 alpha and tumour necrosis factor-alpha in newborn mice.

M Lipoldová 1, V Holán 1
PMCID: PMC1384095  PMID: 2354858

Abstract

Spleen cells from newborn mice are immunologically non-reactive and do not respond by proliferation to T- or B-cell mitogens. However, they synthesize significant levels of mRNA for interleukin-1 alpha (IL-1 alpha) and tumour necrosis factor-alpha (TNF-alpha) after mitogen stimulation. Since these two cytokines mediate many protective activities in the body, they may be important in ensuring the survival of immunologically immature newborns.

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Selected References

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