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. 1991 May;73(1):123–125.

Decreased expression of adhesion molecules on monocytes in recent onset IDDM.

S Martin 1, H Rothe 1, D Tschöpe 1, B Schwippert 1, H Kolb 1
PMCID: PMC1384530  PMID: 1675200

Abstract

The expression of adhesion molecules in monocytes of patients with recent onset type I diabetes was analysed. Monocytes were identified as CD14-positive cells by flow cytometry. The percentage of monocytes expression LFA-1 alpha, ICAM-1 and HLA-DR was slightly lower in recent onset type I diabetes (n = 13) compared to normal subjects (n = 15) and was significantly decreased after activation of cells with lipopolysaccharide and interferon-gamma for 5-24 hr. Receptor densities on adhesion molecule-positive monocytes and the expression of LFA-1 beta were normal. These data indicate that monocyte trafficking is abnormal in recent onset type 1 diabetes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baxevanis C. N., Reclos G. J., Papamichail M. Decreased HLA-DR antigen expression on monocytes causes impaired suppressor cell activity in multiple sclerosis. J Immunol. 1990 Jun 1;144(11):4166–4171. [PubMed] [Google Scholar]
  2. Campbell I. L., Cutri A., Wilkinson D., Boyd A. W., Harrison L. C. Intercellular adhesion molecule 1 is induced on isolated endocrine islet cells by cytokines but not by reovirus infection. Proc Natl Acad Sci U S A. 1989 Jun;86(11):4282–4286. doi: 10.1073/pnas.86.11.4282. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Guerin V., Bene M. C., Amiel C., Hartemann P., Leclere J., Faure G. Decreased lymphocyte function-associated antigen-1 molecule expression on peripheral blood lymphocytes from patients with Graves' disease. J Clin Endocrinol Metab. 1989 Sep;69(3):648–653. doi: 10.1210/jcem-69-3-648. [DOI] [PubMed] [Google Scholar]
  4. Hershman M. J., Cheadle W. G., Wellhausen S. R., Davidson P. F., Polk H. C., Jr Monocyte HLA-DR antigen expression characterizes clinical outcome in the trauma patient. Br J Surg. 1990 Feb;77(2):204–207. doi: 10.1002/bjs.1800770225. [DOI] [PubMed] [Google Scholar]
  5. Kabel P. J., van Dinther A., De Haan-Meulman M., Berghout A., Voorbij H. A., Drexhage H. A. A diminished adherence of blood lymphocytes of patients with thyroid autoimmune disease to high endothelial venules in the thyroid and the thyroid-draining lymph nodes. Autoimmunity. 1990;5(4):247–256. doi: 10.3109/08916939009014709. [DOI] [PubMed] [Google Scholar]
  6. Kishimoto T. K., Larson R. S., Corbi A. L., Dustin M. L., Staunton D. E., Springer T. A. The leukocyte integrins. Adv Immunol. 1989;46:149–182. doi: 10.1016/s0065-2776(08)60653-7. [DOI] [PubMed] [Google Scholar]
  7. Kolb-Bachofen V., Kolb H. A role for macrophages in the pathogenesis of type 1 diabetes. Autoimmunity. 1989;3(2):145–154. doi: 10.3109/08916938909019963. [DOI] [PubMed] [Google Scholar]
  8. Lee K. U., Amano K., Yoon J. W. Evidence for initial involvement of macrophage in development of insulitis in NOD mice. Diabetes. 1988 Jul;37(7):989–991. doi: 10.2337/diab.37.7.989. [DOI] [PubMed] [Google Scholar]
  9. Rothe H., Fehsel K., Kolb H. Tumour necrosis factor alpha production is upregulated in diabetes prone BB rats. Diabetologia. 1990 Sep;33(9):573–575. doi: 10.1007/BF00404147. [DOI] [PubMed] [Google Scholar]
  10. Satoh J., Seino H., Abo T., Tanaka S., Shintani S., Ohta S., Tamura K., Sawai T., Nobunaga T., Oteki T. Recombinant human tumor necrosis factor alpha suppresses autoimmune diabetes in nonobese diabetic mice. J Clin Invest. 1989 Oct;84(4):1345–1348. doi: 10.1172/JCI114304. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Shirakawa F., Yamashita U., Suzuki H. Decrease in HLA-DR-positive monocytes in patients with systemic lupus erythematosus (SLE). J Immunol. 1985 Jun;134(6):3560–3562. [PubMed] [Google Scholar]
  12. Tschoepe D., Spangenberg P., Esser J., Schwippert B., Kehrel B., Roesen P., Gries F. A. Flow-cytometric detection of surface membrane alterations and concomitant changes in the cytoskeletal actin status of activated platelets. Cytometry. 1990;11(5):652–656. doi: 10.1002/cyto.990110515. [DOI] [PubMed] [Google Scholar]
  13. Walker R., Bone A. J., Cooke A., Baird J. D. Distinct macrophage subpopulations in pancreas of prediabetic BB/E rats. Possible role for macrophages in pathogenesis of IDDM. Diabetes. 1988 Sep;37(9):1301–1304. doi: 10.2337/diab.37.9.1301. [DOI] [PubMed] [Google Scholar]

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