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. 1991 Aug;73(4):421–427.

Idiotype specific T-cell lines inducing experimental systemic lupus erythematosus in mice.

H Fricke 1, S Mendlovic 1, M Blank 1, Y Shoenfeld 1, M Ben-Bassat 1, E Mozes 1
PMCID: PMC1384570  PMID: 1916893

Abstract

Immunization of mice with either antibodies bearing the 16/6 idiotype (16/6 Id) or anti-idiotypic antibodies against the 16/6 Id induces experimental systemic lupus erythematosus (SLE). We report here the establishment and characterization of 16/6 Id-specific T-cell lines from C3H.SW (H-2b) and BALB/c (H-2d) mice. Both lines proliferate specifically in response to the 16/6 Id in an H-2-restricted manner. The injection of 16/6 Id-specific T cells into syngeneic mice led to the development of experimental SLE. Furthermore, inoculation of the 16/6 Id-specific T-cell line derived from C3H.SW mice into the H-2 compatible C57BL/6 mice, which are non-responders to the 16/6 Id, induced experimental SLE. This report provides direct evidence for the role of idiotype-specific T cells in the induction of experimental SLE.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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