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. 1991 Aug;73(4):508–509.

Cremophor EL as an adjuvant affecting immunoglobulin class switch in the immune response to the thymus-independent antigen alpha(1- greater than 3) dextran B 1355 S.

F Austrup 1, T Kucharzik 1, E Kölsch 1
PMCID: PMC1384585  PMID: 1717371

Abstract

The humoral immune response to the so-called thymus independent antigen dextran B 1355 S in conventionally raised BALB/c mice consists solely of IgM antibodies. Expression of IgG anti-Dex antibodies in these mice is prevented by pre- or perinatally activated idiotype-specific T-suppressor lymphocytes. IgG B-memory cells nevertheless develop during the course of immunization, but are arrested in an anergic state. In the presence of Cremophor EL the induction of this anergic state is inhibited and the immune response shifts fully to an IgG anti-Dex response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andersen K. E., Nielsen R. Lipstick dermatitis related to castor oil. Contact Dermatitis. 1984 Oct;11(4):253–254. doi: 10.1111/j.1600-0536.1984.tb00996.x. [DOI] [PubMed] [Google Scholar]
  2. Descotes J., Tachon P., Laschi-Locquerie A., Evreux J. C. Adjuvancy of Cremophor Elo in rodents. Int Arch Allergy Appl Immunol. 1983;72(3):287–288. doi: 10.1159/000234883. [DOI] [PubMed] [Google Scholar]
  3. Gleichmann E., Van Elven E. H., Van der Veen J. P. A systemic lupus erythematosus (SLE)-like disease in mice induced by abnormal T-B cell cooperation. Preferential formation of autoantibodies characteristic of SLE. Eur J Immunol. 1982 Feb;12(2):152–159. doi: 10.1002/eji.1830120210. [DOI] [PubMed] [Google Scholar]
  4. Papoian R., Pillarisetty R., Talal N. Immunological regulation of spontaneous antibodies to DNA and RNA. II. Sequential switch from IgM to IgG in NZB/NZW F1 mice. Immunology. 1977 Jan;32(1):75–79. [PMC free article] [PubMed] [Google Scholar]
  5. Schuler W., Lehle G., Weiler E., Kölsch E. Immune response against the T-independent antigen alpha (1 leads to 3) dextran. I. Demonstration of an unexpected IgG response of athymic and germ-free-raised euthymic BALB/c mice. Eur J Immunol. 1982 Feb;12(2):120–125. doi: 10.1002/eji.1830120205. [DOI] [PubMed] [Google Scholar]
  6. Schuler W., Schuler A., Kölsch E. Immune response against the T-independent antigen alpha (1----3) dextran. II. Occurrence of B gamma memory cells in the course of immunization with the native polysaccharide is T cell dependent. Eur J Immunol. 1984 Jun;14(6):578–585. doi: 10.1002/eji.1830140616. [DOI] [PubMed] [Google Scholar]
  7. Stäb F., Austrup F., Kölsch E. Regulation of the anti-alpha(1----3) dextran IgG antibody response of BALB/c mice by idiotype-specific T suppressor lymphocytes. J Immunol. 1990 Jan 1;144(1):53–59. [PubMed] [Google Scholar]
  8. Tachon P., Descotes J., Laschi-Loquerie A., Guillot J. P., Evreux J. C. Assessment of the allergenic potential of althesin and its constituents. Br J Anaesth. 1983 Aug;55(8):715–717. doi: 10.1093/bja/55.8.715. [DOI] [PubMed] [Google Scholar]
  9. Tomonari K. A rat antibody against a structure functionally related to the mouse T-cell receptor/T3 complex. Immunogenetics. 1988;28(6):455–458. doi: 10.1007/BF00355379. [DOI] [PubMed] [Google Scholar]

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