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. 1991 Nov;74(3):561–563.

Soluble CD23 displays T-cell growth enhancing activity.

J C Lecron 1, F Morel 1, J Tanzer 1, J Gombert 1, P Goube de Laforest 1
PMCID: PMC1384656  PMID: 1837537

Abstract

Soluble CD23 (sCD23) enhances, in a dose-dependent manner, the number of secondary T-cell colonies generated by peripheral blood-derived agar T-colony cells in the presence of phytohaemagglutinin (PHA) and interleukin-2 (IL-2). This effect is not affected by IL-1 or IL-4 but is abolished by an anti-CD23 monoclonal antibody (mAb) or by IgE. No colonies were observed when sCD23 was added to PHA- or IL-2-free cultures. sCD23 also enhanced the cloning frequency of primary T-colony cells in a limiting dilution assay. These data provide the first direct evidence that sCD23 recruits T-cell clones in peripheral blood-born T cells and may be involved indirectly in the regulation of IgE response.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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