Abstract
The influence of the In(Lu) gene on human red blood cell (RBC) expression of CDw75 antigens was examined. CDw75 antigens were increased in expression on Lu(a-b-) cells of the dominant inhibitor type in comparison with red cells from donors of other Lutheran (Lu) phenotypes. In contrast, CD44 epitopes detected with F10-44-2, A3D8 and BU52 monoclonal antibodies (mAb) were decreased in expression on Lu(a-b-) red cells. Among normal blood donors of the common phenotype Lu(a-b+) there was a wide range of expression of CDw75 antigens on red cells. The results show that CDw75 is a quantitative polymorphism of human red cells and, among antigens influenced by the In(Lu) gene, is unique in being up-regulated in expression.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Crawford M. N., Tippett P., Sanger R. Antigens Aua, i and P1 of cells of the dominant type of Lu(a-b-). Vox Sang. 1974 Mar;26(3):283–287. doi: 10.1111/j.1423-0410.1974.tb02699.x. [DOI] [PubMed] [Google Scholar]
- Guy K., Andrew J. M. Expression of the CDw75 (beta-galactoside alpha 2,6-sialyltransferase) antigen on normal blood cells and in B-cell chronic lymphocytic leukaemia. Immunology. 1991 Oct;74(2):206–214. [PMC free article] [PubMed] [Google Scholar]
- Hakomori S. Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change. Semin Hematol. 1981 Jan;18(1):39–62. [PubMed] [Google Scholar]
- Marcus D. M., Kundu S. K., Suzuki A. The P blood group system: recent progress in immunochemistry and genetics. Semin Hematol. 1981 Jan;18(1):63–71. [PubMed] [Google Scholar]
- Parsons S. F., Mallinson G., Judson P. A., Anstee D. J., Tanner M. J., Daniels G. L. Evidence that the Lub blood group antigen is located on red cell membrane glycoproteins of 85 and 78 kd. Transfusion. 1987 Jan-Feb;27(1):61–63. doi: 10.1046/j.1537-2995.1987.27187121477.x. [DOI] [PubMed] [Google Scholar]
- Spring F. A., Dalchau R., Daniels G. L., Mallinson G., Judson P. A., Parsons S. F., Fabre J. W., Anstee D. J. The Ina and Inb blood group antigens are located on a glycoprotein of 80,000 MW (the CDw44 glycoprotein) whose expression is influenced by the In(Lu) gene. Immunology. 1988 May;64(1):37–43. [PMC free article] [PubMed] [Google Scholar]
- Stamenkovic I., Asheim H. C., Deggerdal A., Blomhoff H. K., Smeland E. B., Funderud S. The B cell antigen CD75 is a cell surface sialytransferase. J Exp Med. 1990 Aug 1;172(2):641–643. doi: 10.1084/jem.172.2.641. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Telen M. J., Eisenbarth G. S., Haynes B. F. Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene. J Clin Invest. 1983 Jun;71(6):1878–1886. doi: 10.1172/JCI110943. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Weinstein J., de Souza-e-Silva U., Paulson J. C. Sialylation of glycoprotein oligosaccharides N-linked to asparagine. Enzymatic characterization of a Gal beta 1 to 3(4)GlcNAc alpha 2 to 3 sialyltransferase and a Gal beta 1 to 4GlcNAc alpha 2 to 6 sialyltransferase from rat liver. J Biol Chem. 1982 Nov 25;257(22):13845–13853. [PubMed] [Google Scholar]
- Wiels J., Holmes E. H., Cochran N., Tursz T., Hakomori S. Enzymatic and organizational difference in expression of a Burkitt lymphoma-associated antigen (globotriaosylceramide) in Burkitt lymphoma and lymphoblastoid cell lines. J Biol Chem. 1984 Dec 10;259(23):14783–14787. [PubMed] [Google Scholar]