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. 1988 Oct;65(2):323–325.

Alterations in helper-inducer and suppressor-inducer T-cell subsets in human neonatal blood.

R Landesberg 1, M Fallon 1, R Insel 1
PMCID: PMC1384933  PMID: 2973434

Abstract

The distribution of T-helper cell subsets of human umbilical cord lymphocytes was compared with that of adult peripheral blood lymphocytes. Cytofluorometric analysis revealed a similar Leu 3/Leu 2 (helper/suppressor) ratio in neonates compared with adults. Total T-cell numbers were slightly decreased in neonatal blood. The Leu 3-positive-4B4-positive cell (helper-inducer) subset, however, was markedly reduced in neonatal blood, while the Leu 3-positive-2H4-positive cell (suppressor-inducer) subset was increased compared with that of normal adults. These findings may contribute to the poor help and enhanced suppression observed in vitro with neonatal T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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