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. 1988 Jun;64(2):201–205.

Characterization of the IgA receptor from human polymorphonuclear leucocytes.

M Albrechtsen 1, G R Yeaman 1, M A Kerr 1
PMCID: PMC1384943  PMID: 3292406

Abstract

Human polymorphonuclear leucocytes (PMNs) will phagocytose yeasts opsonized with specific affinity-purified human serum IgA. PMNs also bind to Sepharose beads coated with IgA or IgG, but not to beads coated with bovine serum albumin (BSA) or horseradish peroxidase (HRP). Binding to IgA-Sepharose stimulates the cells to release lysozyme. Affinity chromatography of 125I-labelled PMN membrane proteins on IgA-Sepharose results in isolation of a polypeptide of apparent 60,000 MW. The protein, which is not bound to IgG-Sepharose under the same conditions, appears as a diffuse band on SDS-PAGE, suggesting it is heavily glycosylated.

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Selected References

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