Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1988 Jun;64(2):253–259.

Cells involved in the immune response. XXXVI. The thymic antigen-specific suppressor cell in the immunized rabbit is a T cell with receptors for FcG and the antigen and it acts, via a secreted suppressor factor, directly on the immune splenic AFC B cell to inhibit antibody secretion.

E Talor 1, C A Jodouin 1, M Richter 1
PMCID: PMC1384951  PMID: 2455684

Abstract

Following i.v. immunization of the normal outbred rabbit with sheep (SRBC) or horse (HRBC) erythrocytes, antigen-specific suppressor cells are generated in the thymus capable of inhibiting the generation of haemolytic plaques by the autologous or allogeneic splenic antibody-forming cells (AFC) in the plaque-forming cell (PFC) assay. These suppressor cells secrete an antigen-specific suppressor factor in short-term (4-24 hr) culture in vitro. The suppressor cells are not detected in the thymus prior to Day 4, exhibit peak activity between Days 5 and 11 post-immunization, and decline slowly thereafter. Suppressor cells can no longer be detected in the thymus by Day 60 postimmunization. Suppressor cells are not detected in any of the other lymphoid organs of the immunized rabbit nor in any lymphoid organ in the unimmunized rabbit. The thymic suppressor cell is a T cell with surface receptors for the antigen (SRBC or HRBC) and for FcG. On the other hand, the AFC B cells generated in the spleen of the immunized rabbit possess cell-surface receptors for only the antigen and not for FcG. Both the suppressor cells and the secreted suppressor factor act directly on the AFC B lymphocytes to inhibit the generation of antigen-specific haemolytic plaques in the PFC assay.

Full text

PDF
253

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Colas de la Noue H., Koperstych S., Richter M. Cells involved in the immune response. XXII. The demonstration of thymus-specific antigens in the rabbit. Immunology. 1972 Nov;23(5):655–664. [PMC free article] [PubMed] [Google Scholar]
  2. Colas de la Noue H., Richter M. Cells involved in the immune response. XXVI. The demonstration of bone marrow-specific antigens in the rabbit. Immunology. 1974 Sep;27(3):413–420. [PMC free article] [PubMed] [Google Scholar]
  3. Moretta L., Ferrarini M., Durante M. L., Mingari M. C. Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol. 1975 Aug;5(8):565–569. doi: 10.1002/eji.1830050812. [DOI] [PubMed] [Google Scholar]
  4. Moretta L., Mingari M. C., Moretta A., Cooper M. D. Human T lymphocyte subpopulations: studies of the mechanism by which T cells bearing Fc receptors for IgG suppress T-dependent B cell differentiation induced by pokeweed mitogen. J Immunol. 1979 Mar;122(3):984–990. [PubMed] [Google Scholar]
  5. Moretta L., Mingari M. C., Moretta A. Hunan T cell subpopulations in normal and pathologic conditions. Immunol Rev. 1979;45:163–193. doi: 10.1111/j.1600-065x.1979.tb00277.x. [DOI] [PubMed] [Google Scholar]
  6. Moretta L., Moretta A., Canonica G. W., Bacigalupo A., Mingari M. C., Cerottini J. C. Receptors for immunoglobulins on resting and activated human T cells. Immunol Rev. 1981;56:141–162. doi: 10.1111/j.1600-065x.1981.tb01050.x. [DOI] [PubMed] [Google Scholar]
  7. Moretta L., Webb S. R., Grossi C. E., Lydyard P. M., Cooper M. D. Functional analysis of two human T-cell subpopulations: help and suppression of B-cell responses by T cells bearing receptors for IgM or IgG. J Exp Med. 1977 Jul 1;146(1):184–200. doi: 10.1084/jem.146.1.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Richter M., Banerjee D., Sklar S. The antibody-independent cytotoxic activity of normal circulating human leucocytes. II. Failure to demonstrate effector cell-target cell interaction and target cell specificity of the circulating cytotoxic-enhancing factor. Immunology. 1981 Sep;44(1):109–118. [PMC free article] [PubMed] [Google Scholar]
  9. Richter M., Berry M., Barron P. Cells involved in the immune response. XXXI. The role of the spleen in the primary and secondary immune responses in the normal adult outbred rabbit: the initial localization of memory cells to the spleen and their subsequent dissemination to the thymus and peripheral lymph nodes. Clin Immunol Immunopathol. 1986 Jan;38(1):101–110. doi: 10.1016/0090-1229(86)90127-3. [DOI] [PubMed] [Google Scholar]
  10. Richter M., Ettin G., Sklar S., Richter M., Hamdy H., Jodouin C. A., Kazaniwsky N. Surface receptors and immune activity of purified human circulating mononuclear cells. IV. The demonstration of seven subclasses of T cells in the circulation of the normal individual: the cytotoxic activities of these cells. Cell Immunol. 1983 Dec;82(2):352–369. doi: 10.1016/0008-8749(83)90169-7. [DOI] [PubMed] [Google Scholar]
  11. Richter M., Talor E. Cells involved in the immune response. XXXIV: Suppressor cells in the thymus of the immunized rabbit capable of secreting a factor which can suppress the secretion of antibodies from antibody-forming cells in vitro. Clin Immunol Immunopathol. 1986 Dec;41(3):461–478. doi: 10.1016/0090-1229(86)90017-6. [DOI] [PubMed] [Google Scholar]
  12. Sklar S., Richter M., Ettin G., Richter M. Surface receptors and immune activity of purified human circulating mononuclear cells. I. The effects of lysis of the sheep red blood cells (SRBC) in the T-cell rosettes on the receptors and cytotoxic activities of the T cells. T cells with receptors for complement. Immunopharmacology. 1980 Dec;2(4):349–359. doi: 10.1016/0162-3109(80)90019-3. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES