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. 1988 Aug;64(4):633–642.

Down-regulation of suppressor cell induction.

V K Kuchroo 1, T Noma 1, M Minami 1, M E Dorf 1
PMCID: PMC1384984  PMID: 2459051

Abstract

A unidirectional cascade of cell interactions has been described previously that involves at least three distinct populations of suppressor T cells (Ts) that interact in appropriate succession to mediate suppression of delayed hypersensitivity responses to the 4-hydroxy-3-nitrophenylacetyl hapten (NP). The present work focuses on the potential bidirectional effects of one suppressor factor and how it can regulate the homeostatic mechanisms that maintain this suppressor cell cascade. Specifically, the effects of prior administration of mice with a transducer suppressor factor (TsF2) on the generation of NP-specific TS1 suppressor cells were evaluated. It was observed that the TSF2 given 2-14 days prior to administration of the tolerogen (NP-coupled splenic-adherent cells) interfered with the development of inducer TS1 suppressor cells. This down-regulation of suppressor cell induction is mediated by a population of cells that have the following characteristics: NP-binding, Lyt-1+2-, L3T4+, I-J+, and Vicia villosa (VV)-adherent T cells (for convenience these cells are termed anti-suppressor cells). Furthermore, there are genetic restrictions (both H-2 and IgH) between TSF2 and host which control the generation of anti-suppressor cells. The results suggest that TSF2 may have a role in homeostatic mechanisms that regulate the NP-specific suppressor cell cascade. The relationship of anti-suppressor and contra-suppressor cells is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benacerraf B., Germain R. N. A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol. 1981;13(1):1–10. doi: 10.1111/j.1365-3083.1981.tb00104.x. [DOI] [PubMed] [Google Scholar]
  2. Braley-Mullen H. Regulation of the antibody response to type III pneumococcal polysaccharide by contrasuppressor T cells. J Exp Med. 1984 Jul 1;160(1):42–54. doi: 10.1084/jem.160.1.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dorf M. E., Benacerraf B. Suppressor cells and immunoregulation. Annu Rev Immunol. 1984;2:127–157. doi: 10.1146/annurev.iy.02.040184.001015. [DOI] [PubMed] [Google Scholar]
  4. Gershon R. K., Eardley D. D., Durum S., Green D. R., Shen F. W., Yamauchi K., Cantor H., Murphy D. B. Contrasuppression. A novel immunoregulatory activity. J Exp Med. 1981 Jun 1;153(6):1533–1546. doi: 10.1084/jem.153.6.1533. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Green D. R., Eardley D. D., Kimura A., Murphy D. B., Yamauchi K., Gershon R. K. Immunoregulatory circuits which modulate responsiveness to suppressor cell signals: characterization of an effector cell in the contrasuppressor circuit. Eur J Immunol. 1981 Dec;11(12):973–980. doi: 10.1002/eji.1830111205. [DOI] [PubMed] [Google Scholar]
  6. Green D. R., Gershon R. K. Hyperimmunity and the decision to be intolerant. Ann N Y Acad Sci. 1982;392:318–329. doi: 10.1111/j.1749-6632.1982.tb36117.x. [DOI] [PubMed] [Google Scholar]
  7. Green D. R., Gold J., St Martin S., Gershon R., Gershon R. K. Microenvironmental immunoregulation: possible role of contrasuppressor cells in maintaining immune responses in gut-associated lymphoid tissues. Proc Natl Acad Sci U S A. 1982 Feb;79(3):889–892. doi: 10.1073/pnas.79.3.889. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Iverson M., Ptak W., Green D. R., Gershon R. K. Role of contrasuppression in the adoptive transfer of immunity. J Exp Med. 1983 Sep 1;158(3):982–987. doi: 10.1084/jem.158.3.982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jayaraman S., Bellone C. J. Hapten-specific responses to the phenyltrimethylamino hapten. V. A single chain antigen-binding I-J+ first-order T suppressor factor requires antigen to induce anti-idiotypic second-order suppressor T cells. J Immunol. 1985 Feb;134(2):1010–1018. [PubMed] [Google Scholar]
  10. Ju S. T., Benacerraf B., Dorf M. E. Idiotypic analysis of antibodies to poly(Glu60Ala30Tyr10): interstrain and interspecies idiotypic crossreactions. Proc Natl Acad Sci U S A. 1978 Dec;75(12):6192–6196. doi: 10.1073/pnas.75.12.6192. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Minami M., Aoki I., Honji N., Waltenbaugh C. R., Dorf M. E. The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity. J Exp Med. 1983 Nov 1;158(5):1428–1443. doi: 10.1084/jem.158.5.1428. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Minami M., Furusawa S., Dorf M. E. I-J restrictions on the activation and interaction of parental and F1-derived TS3 suppressor cells. J Exp Med. 1982 Aug 1;156(2):465–479. doi: 10.1084/jem.156.2.465. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Minami M., Okuda K., Furusawa S., Benacerraf B., Dorf M. E. Analysis of T cell hybridomas. I. Characterization of H-2 and Igh-restricted monoclonal suppressor factors. J Exp Med. 1981 Nov 1;154(5):1390–1402. doi: 10.1084/jem.154.5.1390. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Okuda K., Minami M., Furusawa M., Dorf M. E. Analysis of T cell hybridomas. II. Comparisons among three distinct types of monoclonal suppressor factors. J Exp Med. 1981 Dec 1;154(6):1838–1851. doi: 10.1084/jem.154.6.1838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Poon R. Y., Kapp J. A., Pierce C. W., Sorensen C. M. Characterization of two monoclonal idiotype-binding suppressor T cell factors specific for the antibody response to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT). J Immunol. 1986 Dec 15;137(12):3709–3716. [PubMed] [Google Scholar]
  16. Ptak W., Bereta M., Marcinkiewicz J., Gershon R. K., Green D. R. Production of antigen-specific contrasuppressor cells and factor, and their use in augmentation of cell-mediated immunity. J Immunol. 1984 Aug;133(2):623–628. [PubMed] [Google Scholar]
  17. Ptak W., Rozycka D., Askenase P. W., Gershon R. K. Role of antigen-presenting cells in the development and persistence of contact hypersensitivity. J Exp Med. 1980 Feb 1;151(2):362–375. doi: 10.1084/jem.151.2.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Reth M., Imanishi-Kari T., Rajewsky K. Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur J Immunol. 1979 Dec;9(12):1004–1013. doi: 10.1002/eji.1830091216. [DOI] [PubMed] [Google Scholar]
  19. Sherr D. H., Dorf M. E. An idiotype-specific helper population that bears immunoglobulin, Ia, and Lyt-1 determinants. J Exp Med. 1984 Apr 1;159(4):1189–1200. doi: 10.1084/jem.159.4.1189. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Sunday M. E., Benacerraf B., Dorf M. E. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. J Exp Med. 1981 Apr 1;153(4):811–822. doi: 10.1084/jem.153.4.811. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Sunday M. E., Weinberger J. Z., Benacerraf B., Dorf M. E. Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. J Immunol. 1980 Oct;125(4):1601–1605. [PubMed] [Google Scholar]
  22. Usui M., Aoki I., Sunshine G. H., Dorf M. E. Requirements for suppressor T cell activation. J Immunol. 1984 Sep;133(3):1137–1141. [PubMed] [Google Scholar]

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