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. 1988 Sep;65(1):143–148.

Histamine synthesis by non-mast cells through mitogen-dependent induction of histidine decarboxylase.

C Oh 1, S Suzuki 1, I Nakashima 1, K Yamashita 1, K Nakano 1
PMCID: PMC1385033  PMID: 3263312

Abstract

Culture of spleen cells of C57BL/6 mice led to a spontaneous increase in activity of histidine decarboxylase (HDC) in the cell and the medium. Concomitantly histamine increased in the cells and, especially, in the medium. Addition of concanavalin A (Con A) or lipopolysaccharide (LPS) to the culture enhanced these processes. There was also a significant Con A-dependent increase in HDC activity and histamine biosynthesis in the culture of spleen cells of genetically mast-cell deficient W/Wv mice. Peritoneal macrophages of C57BL/6J mice had constitutively 11-19-fold as much HDC as T and B lymphocytes when compared on the basis of same number of cells. Con A had no effect on HDC activity when the macrophages were cultured alone. However, co-culture with T lymphocytes, separated from macrophages by a millipore filter membrane (pore size, 0.45 micron), rendered the macrophages responsive to Con A, leading to a notable increase in HDC activity in the cell. Addition of LPS caused a small but significant increase in HDC activity in macrophages, even when the cells were cultured alone. Co-culture with T or B cells enhanced the LPS-dependent increase in HDC activity in macrophages. In contrast, the HDC activity in T and B lymphocytes did not change essentially in the presence of any of these mitogens, even when they were co-cultured with macrophages. These results suggest that histamine is synthesized by non-mast cells through HDC.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brown M. J., Ind P. W., Barnes P. J., Jenner D. A., Dollery C. T. A sensitive and specific radiometric method for the measurement of plasma histamine in normal individuals. Anal Biochem. 1980 Nov 15;109(1):142–146. doi: 10.1016/0003-2697(80)90022-6. [DOI] [PubMed] [Google Scholar]
  2. Busse W. W., Sosman J. Decreased H2 histamine response of granulocytes of asthmatic patients. J Clin Invest. 1977 Jun;59(6):1080–1087. doi: 10.1172/JCI108731. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dy M., Lebel B., Schneider E. Histamine-producing cell stimulating factor (HCSF) and interleukin 3 (IL 3): evidence for two distinct molecular entities. J Immunol. 1986 Jan;136(1):208–212. [PubMed] [Google Scholar]
  4. Dy M., Lebel B. Skin allografts generate an enhanced production of histamine and histamine-producing cell-stimulating factor (HCSF) by spleen cells in response to T cell mitogens. J Immunol. 1983 May;130(5):2343–2347. [PubMed] [Google Scholar]
  5. Griswold D. E., Alessi S., Badger A. M., Poste G., Hanna N. Inhibition of T suppressor cell expression by histamine type 2 (H2) receptor antagonists. J Immunol. 1984 Jun;132(6):3054–3057. [PubMed] [Google Scholar]
  6. Kawaguchi-Nagata K., Okamura H., Tamura T., Yamatodani A., Watanabe T., Wada H., Taguchi T., Kitamura Y., Shoji K. Induction of histidine decarboxylase activity in the spleen of mice treated with staphylococcal enterotoxin A and demonstration of its non-mast cell origin. Biochem Biophys Res Commun. 1985 May 31;129(1):187–192. doi: 10.1016/0006-291x(85)91420-2. [DOI] [PubMed] [Google Scholar]
  7. Kawaguchi-Nagata K., Watanabe T., Yamatodani A., Inoue M., Fujita J., Okamura H., Tamura T., Shoji K., Wada H., Kitamura Y. Induction of histidine decarboxylase in non-mast cells in the spleen of mice by injection of staphylococcal enterotoxin A. J Biochem. 1987 Sep;102(3):551–557. doi: 10.1093/oxfordjournals.jbchem.a122088. [DOI] [PubMed] [Google Scholar]
  8. Khan M. M., Sansoni P., Engleman E. G., Melmon K. L. Pharmacologic effects of autacoids on subsets of T cells. Regulation of expression/function of histamine-2 receptors by a subset of suppressor cells. J Clin Invest. 1985 May;75(5):1578–1583. doi: 10.1172/JCI111863. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Leoutsakos A., Pearce F. L. The effect of adenosine and its analogues on cyclic AMP changes and histamine secretion from rat peritoneal mast cells stimulated by various ligands. Biochem Pharmacol. 1986 Apr 15;35(8):1373–1379. doi: 10.1016/0006-2952(86)90284-4. [DOI] [PubMed] [Google Scholar]
  10. Li C. Y., Lam K. W., Yam L. T. Esterases in human leukocytes. J Histochem Cytochem. 1973 Jan;21(1):1–12. doi: 10.1177/21.1.1. [DOI] [PubMed] [Google Scholar]
  11. Nakano K., Suzuki S., Chanho O., Yamashita K. Possible role of glucocorticoids in a complement-activated state induced by cobra venom factor in rats. Acta Endocrinol (Copenh) 1986 May;112(1):122–129. doi: 10.1530/acta.0.1120122. [DOI] [PubMed] [Google Scholar]
  12. Nakano T., Sonoda T., Hayashi C., Yamatodani A., Kanayama Y., Yamamura T., Asai H., Yonezawa T., Kitamura Y., Galli S. J. Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Exp Med. 1985 Sep 1;162(3):1025–1043. doi: 10.1084/jem.162.3.1025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Schayer R. W. Histamine and stress responses of lymphoid tissues. Endocrinology. 1967 Dec;81(6):1357–1361. doi: 10.1210/endo-81-6-1357. [DOI] [PubMed] [Google Scholar]
  14. Suzuki S., Nakano K. LPS-caused secretion of corticosterone is mediated by histamine through histidine decarboxylase. Am J Physiol. 1986 Mar;250(3 Pt 1):E243–E247. doi: 10.1152/ajpendo.1986.250.3.E243. [DOI] [PubMed] [Google Scholar]
  15. Suzuki S., Nakano K. Possible role of endogenous histamine in mediation of LPS-induced secretion of corticosterone in mice. Biochem Pharmacol. 1986 Sep 15;35(18):3039–3043. doi: 10.1016/0006-2952(86)90383-7. [DOI] [PubMed] [Google Scholar]
  16. Taguchi Y., Tsuyama K., Watanabe T., Wada H., Kitamura Y. Increase in histidine decarboxylase activity in skin of genetically mast-cell-deficient W/Wv mice after application of phorbol 12-myristate 13-acetate: evidence for the presence of histamine-producing cells without basophilic granules. Proc Natl Acad Sci U S A. 1982 Nov;79(22):6837–6841. doi: 10.1073/pnas.79.22.6837. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Vogel S. N., Hilfiker M. L., Caulfield M. J. Endotoxin-induced T lymphocyte proliferation. J Immunol. 1983 Apr;130(4):1774–1779. [PubMed] [Google Scholar]
  18. WoldeMussie E., Aiken D., Beaven M. A. Evidence for rapid histamine turnover and loss of histamine from immature rat mast cells. Biochem Pharmacol. 1986 Mar 15;35(6):903–909. doi: 10.1016/0006-2952(86)90075-4. [DOI] [PubMed] [Google Scholar]

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