Skip to main content
NCBI home page
Immunology logoLink to Immunology
. 1988 Jul;64(3):539–544.

Postnatal development and lymphocyte production of jejunal and ileal Peyer's patches in normal and gnotobiotic pigs.

R Pabst 1, M Geist 1, H J Rothkötter 1, F J Fritz 1
PMCID: PMC1385070  PMID: 3410497

Abstract

The development of the number, size, structure and proliferative capacity of Peyer's patches (PP) in the jejunum and ileum has been studied during the early postnatal period of conventional and germ-free pigs. A mean of 15 discrete PP in the jejunum and upper ileum (jejPP) were counted at birth, and the number increased only gradually. A continuous PP is located in the terminal ileum (ileal PP). The length of both jejPP and ileal PP increased with age due to the increase in follicle size and in the number of follicles in the ileal PP. In older pigs, only the ileal PP regressed to small scattered follicles. In germ-free piglets at 39 and 59 days of age, longer PP were found than in normal new-born piglets, but they were significantly shorter than in age-matched controls. Lymphocyte production was studied by the metaphase-arrest technique using vincristine. Lymphocyte production in follicles increased dramatically with age, while in other compartments, such as the inter-follicular and dome area, a low age-independent production of lymphocytes was found. There were no differences in lymphocytopoiesis between jejPP and ileal PP. The present data show major differences in the development, structure and function of PP in pigs in comparison to other species. These species-specific aspects are important for future studies on the immunological function of PP.

Full text

PDF
539

Images in this article

540Figure 1
on p.540
541Figure 5
on p.541

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson J. C. The response of gut-associated lymphoid tissue in gnotobiotic piglets to the presence of bacterial antigen in the alimentary tract. J Anat. 1977 Dec;124(Pt 3):555–562. [PMC free article] [PubMed] [Google Scholar]
  2. Binns R. M., Licence S. T. Patterns of migration of labelled blood lymphocyte subpopulations: evidence for two types of Peyer's patch in the young pig. Adv Exp Med Biol. 1985;186:661–668. doi: 10.1007/978-1-4613-2463-8_81. [DOI] [PubMed] [Google Scholar]
  3. Brandtzaeg P. Research in gastrointestinal immunology. State of the art. Scand J Gastroenterol Suppl. 1985;114:137–156. doi: 10.3109/00365528509093774. [DOI] [PubMed] [Google Scholar]
  4. Chapman H. A., Johnson J. S., Cooper M. D. Ontogeny of Peyer's patches and immunoglobulin-containing cells in pigs. J Immunol. 1974 Feb;112(2):555–563. [PubMed] [Google Scholar]
  5. Chu R. M., Glock R. D., Ross R. F. Changes in gut-associated lymphoid tissues of the small intestine of eight-week-old pigs infected with transmissible gastroenteritis virus. Am J Vet Res. 1982 Jan;43(1):67–76. [PubMed] [Google Scholar]
  6. Chu R. M., Glock R. D., Ross R. F., Cox D. F. Lymphoid tissues of the small intestine of swine from birth to one month of age. Am J Vet Res. 1979 Dec;40(12):1713–1719. [PubMed] [Google Scholar]
  7. Chu R. M., Glock R. D., Ross R. F. Gut-associated lymphoid tissues of young swine with emphasis on dome epithelium of aggregated lymph nodules (Peyer's patches) of the small intestine. Am J Vet Res. 1979 Dec;40(12):1720–1728. [PubMed] [Google Scholar]
  8. Chu R. M., Liu C. H. Morphological and functional comparisons of Peyer's patches in different parts of the swine small intestine. Vet Immunol Immunopathol. 1984 Jul;6(3-4):391–403. doi: 10.1016/0165-2427(84)90063-1. [DOI] [PubMed] [Google Scholar]
  9. Cornes J. S. Number, size, and distribution of Peyer's patches in the human small intestine: Part I The development of Peyer's patches. Gut. 1965 Jun;6(3):225–229. doi: 10.1136/gut.6.3.225. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Dziaba K. A., Lambrecht G., Petzoldt K. Intestinal and serum antibody response in gnotobiotic piglets to oral immunization with Escherichia coli. Comp Immunol Microbiol Infect Dis. 1985;8(3-4):267–272. doi: 10.1016/0147-9571(85)90005-0. [DOI] [PubMed] [Google Scholar]
  11. Gerber H. A., Morris B., Trevella W. The role of gut-associated lymphoid tissues in the generation of immunoglobulin-bearing lymphocytes in sheep. Aust J Exp Biol Med Sci. 1986 Jun;64(Pt 3):201–213. doi: 10.1038/icb.1986.22. [DOI] [PubMed] [Google Scholar]
  12. Pabst R., Fritz F. J. Comparison of lymphocyte production in lymphoid organs and their compartments using the metaphase-arrest technique. Cell Tissue Res. 1986;245(2):423–430. doi: 10.1007/BF00213950. [DOI] [PubMed] [Google Scholar]
  13. Pabst R., Reynolds J. D. Evidence of extensive lymphocyte death in sheep Peyer's patches. II. The number and fate of newly-formed lymphocytes that emigrate from Peyer's patches. J Immunol. 1986 Mar 15;136(6):2011–2017. [PubMed] [Google Scholar]
  14. Pabst R. The anatomical basis for the immune function of the gut. Anat Embryol (Berl) 1987;176(2):135–144. doi: 10.1007/BF00310046. [DOI] [PubMed] [Google Scholar]
  15. Reynolds J. D. Evidence of differences between Peyer's patches and germinal centers. Adv Exp Med Biol. 1985;186:111–118. doi: 10.1007/978-1-4613-2463-8_13. [DOI] [PubMed] [Google Scholar]
  16. Reynolds J. D. Evidence of extensive lymphocyte death in sheep Peyer's patches. I. A comparison of lymphocyte production and export. J Immunol. 1986 Mar 15;136(6):2005–2010. [PubMed] [Google Scholar]
  17. Reynolds J. D. Mitotic rate maturation in the Peyer's patches of fetal sheep and in the bursa of Fabricius of the chick embryo. Eur J Immunol. 1987 Apr;17(4):503–507. doi: 10.1002/eji.1830170411. [DOI] [PubMed] [Google Scholar]
  18. Reynolds J. D., Morris B. The evolution and involution of Peyer's patches in fetal and postnatal sheep. Eur J Immunol. 1983 Aug;13(8):627–635. doi: 10.1002/eji.1830130805. [DOI] [PubMed] [Google Scholar]
  19. Reynolds J. D. Peyer's patches and the early development of B lymphocytes. Curr Top Microbiol Immunol. 1987;135:43–56. doi: 10.1007/978-3-642-71851-9_3. [DOI] [PubMed] [Google Scholar]
  20. Reynolds J., Pabst R., Bordmann G. Evidence for the existence of two distinct types of Peyer's patches in sheep. Adv Exp Med Biol. 1985;186:101–109. doi: 10.1007/978-1-4613-2463-8_12. [DOI] [PubMed] [Google Scholar]
  21. Sminia T., Janse E. M., Plesch B. E. Ontogeny of Peyer's patches of the rat. Anat Rec. 1983 Oct;207(2):309–316. doi: 10.1002/ar.1092070209. [DOI] [PubMed] [Google Scholar]
  22. Torres-Medina A. Morphologic characteristics of the epithelial surface of aggregated lymphoid follicles (Peyer's patches) in the small intestine of newborn gnotobiotic calves and pigs. Am J Vet Res. 1981 Feb;42(2):232–236. [PubMed] [Google Scholar]
  23. Tzipori S., Robins-Browne R. M., Gonis G., Hayes J., Withers M., McCartney E. Enteropathogenic Escherichia coli enteritis: evaluation of the gnotobiotic piglet as a model of human infection. Gut. 1985 Jun;26(6):570–578. doi: 10.1136/gut.26.6.570. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Werhahn E., Klobasa F., Butler J. E. Investigation of some factors which influence the absorption of IgG by the neonatal piglet. Vet Immunol Immunopathol. 1981 Feb;2(1):35–51. doi: 10.1016/0165-2427(81)90037-4. [DOI] [PubMed] [Google Scholar]

Articles from Immunology are provided here courtesy of British Society for Immunology

RESOURCES