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. 1989 May;67(1):129–131.

Human thyroglobulin autoantibodies of subclasses IgG2 and IgG4 bind to different epitopes on thyroglobulin.

N Fukuma 1, S M McLachlan 1, V B Petersen 1, P Kau 1, J Bradbury 1, M Devey 1, K Bleasdale 1, P Grabowski 1, B R Smith 1
PMCID: PMC1385301  PMID: 2472355

Abstract

IgG autoantibodies to thyroglobulin (Tg) in the serum of patients with autoimmune thyroid disease only recognize a very limited number of epitopes, probably between four and six (Nye, Pontes De Carvalho & Roitt, 1980) on the large Tg molecule (660,000 MW), but attempts to characterize the epitopes have been unsuccessful so far (Male et al., 1985). The distribution of Tg autoantibodies between the IgG subclasses also tends to be restricted and individual patients possess characteristic 'fingerprints' of high affinity IgG1 and/or IgG4 Tg antibodies with smaller amounts of IgG2 Tg antibody (McLachlan et al., 1987, 1988). We have therefore investigated the possibility that Tg autoantibodies of different IgG subclasses interact with different epitopes on Tg.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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