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. 1989 Aug;67(4):520–524.

Interferon-gamma as an adjuvant in immunocompromised mice.

A W Heath 1, M E Devey 1, I N Brown 1, C E Richards 1, J H Playfair 1
PMCID: PMC1385324  PMID: 2504662

Abstract

We have compared interferon-gamma (IFN-gamma) with saponin and interleukin-1 (IL-1) as adjuvants for a blood-stage malaria vaccine in mice with various immunological abnormalities. IFN-gamma was particularly effective in Biozzi low antibody responder mice, mice selectively bred to produce antibody of low affinity, and mice depleted of CD4+ T cells. IFN-gamma and other cytokines may be safe adjuvants for use in human immunodeficiency states.

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Selected References

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