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. 1989 Jul;67(3):339–343.

The role of CD4+ lymphocytes in the activation of non-specific suppressor cells by antigen.

H Stefanovic 1, C Izaguirre 1, L G Filion 1
PMCID: PMC1385350  PMID: 2527195

Abstract

Tetanus toxoid (TT) and hepatitis B surface antigen (HBsAg) can suppress lectin-induced responses. The suppression induced by TT is dose-dependent and can also down-regulate the induction of a blastogenic response by anti-CD3 and anti-CD4 monoclonals. In addition, TT can dampen the blastogenic response induced by phytohaemagglutinin (PHA) and anti-CD3. The cellular mechanism involved in the turning off of the blastogenic response was investigated by transferring cells treated for 5 days with TT to freshly obtained syngeneic cells and stimulation with PHA. The response of cultures that had received TT-treated cells was significantly lower than of those that had received cells treated with medium only. The removal of CD4+ cells at the induction phase of the suppression reversed the suppression, whereas the elimination of most CD8+ cells had no effect. We propose that CD4+ cells together with monocytes can dampen the specific and non-specific blastogenic responses.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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