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. 1988 Dec;65(4):647–649.

Tumour necrosis factors modulate the affinity state of the leukotriene B4 receptor on human neutrophils.

J Brom 1, J Knöller 1, M Köller 1, W König 1
PMCID: PMC1385578  PMID: 2851543

Abstract

Pre-incubation of human polymorphonuclear granulocytes with recombinant human tumour necrosis factors (TNF) revealed a time- and dose-dependent reduction of the expression of leukotriene B4-receptor sites. Analysis of the binding data by Scatchard plots showed a shift from a heterologous receptor population (indicating high- and low-affinity subsets) to a homologous population. From the results it is considered that TNF can influence host defence through the modulation of leukotriene B4 receptor affinity.

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Selected References

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