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. 1990 Feb;69(2):171–176.

Neutralizing antibodies to all seven serotypes of foot-and-mouth disease virus elicited by synthetic peptides.

M J Francis 1, G Z Hastings 1, B E Clarke 1, A L Brown 1, C R Beddell 1, D J Rowlands 1, F Brown 1
PMCID: PMC1385585  PMID: 2155177

Abstract

Uncoupled peptides from all seven serotypes of foot-and-mouth disease virus (FMDV) protein VP1 have been used to elicit neutralizing antibody responses in guinea-pigs. The responses were largely serotype specific, although some significant cross-neutralization was observed. Dimeric tandem peptides have also been used to simultaneously elicit neutralizing antibodies to two different FMDV serotypes. The possible existence of structural features common to the B-cell neutralization sites or the guinea-pig helper T-cell sites within all seven peptides are analysed and discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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