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. 1990 Apr;69(4):554–557.

Human IFN-gamma up-regulates IL-2 receptors in mitogen-activated T lymphocytes.

M A Rodriguez 1, J B De Sanctis 1, A M Blasini 1, M Leon-Ponte 1, I Abadi 1
PMCID: PMC1385628  PMID: 2110548

Abstract

This study examined the role of human recombinant interferon-gamma (rIFN-gamma) in the expression of interleukin-2 receptors (IL-2R) by human T lymphocytes. rIFN-gamma enhanced total numbers of IL-2R in mitogen-activated but not resting T cells. Scatchard plot analysis indicated that rIFN-gamma increased both high- and low-affinity receptors, with a predominant effect on the latter. Phytohaemagglutinin (PHA)-activated T cells treated with IFN-gamma showed higher IL-2 binding and greater IL-2 internalization and degradation than cells treated with PHA alone. There was a corresponding increase of mitogen-driven proliferative responses, indicating an increase of functional receptors in IFN-treated cultures. IFN-gamma may influence T-cell activation and proliferation by enhancing expression of IL-2R and promoting IL-2 uptake by mitogen-activated lymphocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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