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. 1987 Apr;23(4):391–396. doi: 10.1111/j.1365-2125.1987.tb03067.x

Effects of felodipine on haemodynamics and exercise capacity in patients with angina pectoris.

J V Sheridan, P Thomas, P A Routledge, D J Sheridan
PMCID: PMC1386087  PMID: 3107605

Abstract

We studied the effects of adding felodipine to beta-adrenoceptor blockade on haemodynamics and exercise capacity in 14 patients with stable angina pectoris using a placebo controlled double-blind crossover protocol. Felodipine reduced supine and standing systolic pressure by 13% (P less than 0.01) and 14% (P less than 0.01) respectively and increased supine heart rate 7.4% (P less than 0.05). Felodipine at a plasma concentration of 15.5 +/- 3.0 nmol l-1 increased exercise duration by 16% (P less than 0.01) but failed to attenuate the degree of ST segment depression during exercise. The mean daily number of episodes of angina (0.53 +/- 0.16 on placebo vs 0.37 +/- 0.11 on felodipine) and mean daily GTN consumption (0.51 +/- 0.07 on placebo vs 0.36 +/- 0.12 on felodipine) were not significantly reduced (0.1 less than P greater than 0.05). These findings suggest that felodipine may provide useful additional benefits in patients with hypertension or angina pectoris, who are already receiving beta-adrenoceptor blockers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ahnoff M. Determination of felodipine in plasma by capillary gas chromatography with electron capture detection. J Pharm Biomed Anal. 1984;2(3-4):519–526. doi: 10.1016/0731-7085(84)80055-2. [DOI] [PubMed] [Google Scholar]
  2. Andersson O. K., Granérus G., Hedner T., Wysocki M. Systemic and renal hemodynamic effects of single oral doses of felodipine in patients with refractory hypertension receiving chronic therapy with beta-blockers and diuretics. J Cardiovasc Pharmacol. 1985 May-Jun;7(3):544–549. doi: 10.1097/00005344-198505000-00021. [DOI] [PubMed] [Google Scholar]
  3. Bostróm S. L., Ljung B., Mårdh S., Forsen S., Thulin E. Interaction of the antihypertensive drug felodipine with calmodulin. Nature. 1981 Aug 20;292(5825):777–778. doi: 10.1038/292777a0. [DOI] [PubMed] [Google Scholar]
  4. Collins P., Sheridan D. Improvement in angina pectoris with alpha adrenoceptor blockade. Br Heart J. 1985 May;53(5):488–492. doi: 10.1136/hrt.53.5.488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Culling W., Ruttley M. S., Sheridan D. J. Acute haemodynamic effects of felodipine during beta blockade in patients with coronary artery disease. Br Heart J. 1984 Oct;52(4):431–434. doi: 10.1136/hrt.52.4.431. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dawson J. R., Whitaker N. H., Sutton G. C. Calcium antagonist drugs in chronic stable angina. Comparison of verapamil and nifedipine. Br Heart J. 1981 Nov;46(5):508–512. doi: 10.1136/hrt.46.5.508. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Johnsson G., Murray G., Tweddel A., Hutton I. Haemodynamic effects of a new vasodilator drug, felodipine, in healthy subjects. Eur J Clin Pharmacol. 1983;24(1):49–53. doi: 10.1007/BF00613926. [DOI] [PubMed] [Google Scholar]
  8. Joshi P. I., Dalal J. J., Ruttley M. S., Sheridan D. J., Henderson A. H. Nifedipine and left ventricular function in beta-blocked patients. Br Heart J. 1981 Apr;45(4):457–459. doi: 10.1136/hrt.45.4.457. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Leonetti G., Gradnik R., Terzoli L., Fruscio M., Rupoli L., Zanchetti A. Felodipine, a new vasodilating drug: blood pressure, cardiac, renal, and humoral effects in hypertensive patients. J Cardiovasc Pharmacol. 1984 May-Jun;6(3):392–398. [PubMed] [Google Scholar]
  10. McNeil J. J., Louis W. J. A double-blind crossover comparison of pindolol, metoprolol, atenolol and labetalol in mild to moderate hypertension. Br J Clin Pharmacol. 1979;8(Suppl 2):163S–166S. [PMC free article] [PubMed] [Google Scholar]
  11. Rowland E., Razis P., Sugrue D., Krikler D. M. Acute and chronic haemodynamic and electrophysiological effects of nifedipine in patients receiving atenolol. Br Heart J. 1983 Oct;50(4):383–389. doi: 10.1136/hrt.50.4.383. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Tweddel A. C., Johnsson G., Pringle T. H., Murray R. G., Hutton I. The systemic and coronary haemodynamic effects of felodipine in patients with coronary heart disease. Eur Heart J. 1983 Oct;4(10):699–705. doi: 10.1093/oxfordjournals.eurheartj.a061381. [DOI] [PubMed] [Google Scholar]
  13. Winniford M. D., Huxley R. L., Hillis L. D. Randomized, double-blind comparison of propranolol alone and a propranolol-verapamil combination in patients with severe angina of effort. J Am Coll Cardiol. 1983 Feb;1(2 Pt 1):492–498. doi: 10.1016/s0735-1097(83)80078-3. [DOI] [PubMed] [Google Scholar]

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