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. 1987 Apr;23(4):397–401. doi: 10.1111/j.1365-2125.1987.tb03068.x

Effect of guanfacine on ambulatory blood pressure and its variability in elderly patients with essential hypertension.

A G Dupont, P Vanderniepen, R O Six
PMCID: PMC1386088  PMID: 3555578

Abstract

The effect of guanfacine (2 mg once daily) on ambulatory blood pressure was studied with the Remler M 2000 recorder in 16 elderly hypertensive patients during a randomized, double-blind, placebo-controlled, balanced, cross-over study. Guanfacine significantly reduced heart rate and systolic and diastolic ambulatory blood pressure. The antihypertensive effect was maintained over the whole recording period. Systolic and diastolic blood pressure variability was not changed by guanfacine, neither when defined as standard deviation or variation coefficient of the mean, nor when defined as the range between the highest and lowest ambulatory blood pressure, suggesting that blood pressure variability is unrelated to sympathetic nervous system activity.

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Selected References

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  1. Brunner H. R., Waeber B., Nussberger J. Blood pressure recording in the ambulatory patient and evaluation of cardiovascular risk. Clin Sci (Lond) 1985 May;68(5):485–488. doi: 10.1042/cs0680485. [DOI] [PubMed] [Google Scholar]
  2. Conway J., Boon N., Davies C., Jones J. V., Sleight P. Neural and humoral mechanisms involved in blood pressure variability. J Hypertens. 1984 Apr;2(2):203–208. doi: 10.1097/00004872-198404000-00013. [DOI] [PubMed] [Google Scholar]
  3. Drayer J. I., Weber M. A., DeYoung J. L., Wyle F. A. Circadian blood pressure patterns in ambulatory hypertensive patients: effects of age. Am J Med. 1982 Oct;73(4):493–499. doi: 10.1016/0002-9343(82)90327-8. [DOI] [PubMed] [Google Scholar]
  4. Fitzgerald D. J., O'Callaghan W. G., McQuaid R., O'Malley K., O'Brien E. Accuracy and reliability of two indirect ambulatory blood pressure recorders: Remler M2000 and Cardiodyne Sphygmolog. Br Heart J. 1982 Dec;48(6):572–579. doi: 10.1136/hrt.48.6.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gribbin B., Pickering T. G., Sleight P., Peto R. Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res. 1971 Oct;29(4):424–431. doi: 10.1161/01.res.29.4.424. [DOI] [PubMed] [Google Scholar]
  6. Horan M. J., Padgett N. E., Kennedy H. L. Ambulatory blood pressure monitoring: recent advances and clinical applications. Am Heart J. 1981 Jun;101(6):843–848. doi: 10.1016/0002-8703(81)90623-2. [DOI] [PubMed] [Google Scholar]
  7. Jacot-des-Combes B., Brunner H. R., Waeber B., Porchet M., Biollaz J. Blood pressure variability in ambulatory hypertensive patients: effect of beta-blocking agents and/or diuretics. J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):263–266. doi: 10.1097/00005344-198403000-00009. [DOI] [PubMed] [Google Scholar]
  8. Lake C. R., Ziegler M. G., Coleman M. D., Kopin I. J. Age-adjusted plasma norepinephrine levels are similar in normotensive and hypertensive subjects. N Engl J Med. 1977 Jan 27;296(4):208–209. doi: 10.1056/NEJM197701272960408. [DOI] [PubMed] [Google Scholar]
  9. Mancia G. Blood pressure variability at normal and high blood pressure. Chest. 1983 Feb;83(2 Suppl):317–320. doi: 10.1378/chest.83.2.317. [DOI] [PubMed] [Google Scholar]
  10. Mancia G., Parati G., Pomidossi G., Di Rienzo M. Validity and usefulness of non-invasive ambulatory blood pressure monitoring. J Hypertens Suppl. 1985 Nov;3(2):S5–11. [PubMed] [Google Scholar]
  11. Mann S., Millar Craig M. W., Melville D. I., Cashman P. M., Raftery E. B. An ambulatory trial of guanfacine. Br J Clin Pharmacol. 1980;10 (Suppl 1):103S–107S. doi: 10.1111/j.1365-2125.1980.tb04915.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Perloff D., Sokolow M., Cowan R. The prognostic value of ambulatory blood pressures. JAMA. 1983 May 27;249(20):2792–2798. [PubMed] [Google Scholar]
  13. Rowlands D. B., Stallard T. J., Littler W. A. Comparison of ambulatory blood pressure and cardiovascular reflexes in elderly hypertensives, elderly normotensives and young hypertensives. J Hypertens Suppl. 1983 Dec;1(2):71–73. [PubMed] [Google Scholar]
  14. Sever P. S., Osikowska B., Birch M., Tunbridge R. D. Plasma-noradrenaline in essential hypertension. Lancet. 1977 May 21;1(8021):1078–1081. doi: 10.1016/s0140-6736(77)92335-2. [DOI] [PubMed] [Google Scholar]
  15. Sleight P. Differences between casual and 24-h blood pressures. J Hypertens Suppl. 1985 Nov;3(2):S19–S23. [PubMed] [Google Scholar]
  16. Sokolow M., Werdegar D., Kain H. K., Hinman A. T. Relationship between level of blood pressure measured casually and by portable recorders and severity of complications in essential hypertension. Circulation. 1966 Aug;34(2):279–298. doi: 10.1161/01.cir.34.2.279. [DOI] [PubMed] [Google Scholar]
  17. Sorkin E. M., Heel R. C. Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs. 1986 Apr;31(4):301–336. doi: 10.2165/00003495-198631040-00003. [DOI] [PubMed] [Google Scholar]
  18. Sowers J. R., Rubenstein L. Z., Stern N. Plasma norepinephrine responses to posture and isometric exercise increase with age in the absence of obesity. J Gerontol. 1983 May;38(3):315–317. doi: 10.1093/geronj/38.3.315. [DOI] [PubMed] [Google Scholar]
  19. Waeber B., Jacot des Combes B., Porchet M., Biollaz J., Schaller M. D., Brunner H. R. Ambulatory blood pressure recording to identify hypertensive patients who truly need therapy. J Chronic Dis. 1984;37(1):55–57. doi: 10.1016/0021-9681(84)90125-5. [DOI] [PubMed] [Google Scholar]
  20. Watson R. D., Stallard T. J., Flinn R. M., Littler W. A. Factors determining direct arterial pressure and its variability in hypertensive man. Hypertension. 1980 May-Jun;2(3):333–341. doi: 10.1161/01.hyp.2.3.333. [DOI] [PubMed] [Google Scholar]
  21. des Combes B. J., Porchet M., Waeber B., Brunner H. R. Ambulatory blood pressure recordings. Reproducibility and unpredictability. Hypertension. 1984 Jan-Feb;6(1):110–114. [PubMed] [Google Scholar]
  22. di Rienzo M., Grassi G., Pedotti A., Mancia G. Continuous vs intermittent blood pressure measurements in estimating 24-hour average blood pressure. Hypertension. 1983 Mar-Apr;5(2):264–269. doi: 10.1161/01.hyp.5.2.264. [DOI] [PubMed] [Google Scholar]

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