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. 1987 Apr;23(4):482–485. doi: 10.1111/j.1365-2125.1987.tb03080.x

Evidence for polymorphic oxidation of sparteine in Japanese subjects.

T Ishizaki, M Eichelbaum, Y Horai, K Hashimoto, K Chiba, H J Dengler
PMCID: PMC1386100  PMID: 3580254

Abstract

The metabolism of sparteine which exhibits a genetic polymorphism in Caucasians was studied in 84 unrelated Japanese subjects. In contrast to a recent study where debrisoquine was used as a probe and no poor metabolizers could be observed in Japanese involving 100 subjects, two subjects had a urinary metabolic ratio of sparteine greater than 20 and thus were poor metabolizers of sparteine. The incidence of poor metabolizer phenotype of sparteine oxidation of 2% seems to be lower in Japanese as compared with various Caucasian populations where 5 to 10% are poor metabolizers of sparteine. However, this is not conclusive, because the 95% confidence interval of the observed frequency, 0.6 to 8%, covers the range reported in the literature for Caucasians.

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Selected References

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