Abstract
Intravenous enalaprilic acid (2.5 mg) was given to 11 patients with stable cardiac failure (NYHA functional class II-IV). Reductions in mean right atrial, pulmonary artery and pulmonary capillary wedge pressure of 25%, 18% and 30% respectively (P less than 0.01), were observed. Cardiac output rose by 13% (NS) and mean blood pressure fell by 20% (P less than 0.01) with a decrease in systemic vascular resistance of 24% (P less than 0.01). Heart rate was unaltered. The haemodynamic effects correlated with control plasma renin activity (r = 0.78, P less than 0.01). Marked hypotension occurred in several subjects but no other side-effects were noted. The rapid onset of action and mixed venous and arteriolar dilating activity of intravenous enalaprilic acid may be an advantage in some clinical situations where parenteral vasodilating therapy is required.
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Selected References
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- Cleland J. G., Dargie H. J., McAlpine H., Ball S. G., Morton J. J., Robertson J. I., Ford I. Severe hypotension after first dose of enalapril in heart failure. Br Med J (Clin Res Ed) 1985 Nov 9;291(6505):1309–1312. doi: 10.1136/bmj.291.6505.1309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cody R. J., Jr, Bravo E. L., Fouad F. M., Tarazi R. C. Cardiovascular reflexes during long-term converting enzyme inhibition and sodium depletion. The response to tilt in hypertensive patients. Am J Med. 1981 Sep;71(3):422–426. doi: 10.1016/0002-9343(81)90170-4. [DOI] [PubMed] [Google Scholar]
- Hodsman G. P., Isles C. G., Murray G. D., Usherwood T. P., Webb D. J., Robertson J. I. Factors related to first dose hypotensive effect of captopril: prediction and treatment. Br Med J (Clin Res Ed) 1983 Mar 12;286(6368):832–834. doi: 10.1136/bmj.286.6368.832. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kramer B., Topic N., Massie B. Acute and long-term effects of captopril on exercise cardiac performance and exercise capacity in congestive heart failure. Br J Clin Pharmacol. 1982;14 (Suppl 2):143S–151S. doi: 10.1111/j.1365-2125.1982.tb02071.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lee W. B., Ismay M. J., Lumbers E. R. Mechanisms by which angiotensin II affects the heart rate of the conscious sheep. Circ Res. 1980 Aug;47(2):286–292. doi: 10.1161/01.res.47.2.286. [DOI] [PubMed] [Google Scholar]
- Levine T. B., Franciosa J. A., Cohn J. N. Acute and long-term response to an oral converting-enzyme inhibitor, captopril, in congestive heart failure. Circulation. 1980 Jul;62(1):35–41. doi: 10.1161/01.cir.62.1.35. [DOI] [PubMed] [Google Scholar]
- Marker J. D., Miles T. S., Scroop G. C. Modulation of the baroreceptor reflex by angiotensin II and other vasoactive drugs in anaesthetized greyhounds. Clin Sci (Lond) 1980 Jan;58(1):7–13. doi: 10.1042/cs0580007. [DOI] [PubMed] [Google Scholar]
- Sharpe D. N., Murphy J., Coxon R., Hannan S. F. Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study. Circulation. 1984 Aug;70(2):271–278. doi: 10.1161/01.cir.70.2.271. [DOI] [PubMed] [Google Scholar]