Abstract
The effect of a potent inhibitor of angiotensin-converting enzyme, ramipril, was studied on both inhaled histamine and bradykinin-induced bronchoconstriction in six male, normotensive, mild asthmatic subjects. Oral administration of 10 mg ramipril caused no change in lung function or airway reactivity to inhaled histamine or bradykinin despite achieving adequate reduction in angiotensin-converting enzyme activity.
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Selected References
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- Chowienczyk P. J., Rees P. J., Payne J., Clark T. J. A new method for computer-assisted determination of airways resistance. J Appl Physiol Respir Environ Exerc Physiol. 1981 Mar;50(3):672–678. doi: 10.1152/jappl.1981.50.3.672. [DOI] [PubMed] [Google Scholar]
- Maguire G. A., Price C. P. A continuous monitoring spectrophotometric method for the measurement of angiotensin-converting enzyme in human serum. Ann Clin Biochem. 1985 Mar;22(Pt 2):204–210. doi: 10.1177/000456328502200218. [DOI] [PubMed] [Google Scholar]
- Regoli D., Barabé J. Pharmacology of bradykinin and related kinins. Pharmacol Rev. 1980 Mar;32(1):1–46. [PubMed] [Google Scholar]
- Semple P. F., Herd G. W. Cough and wheeze caused by inhibitors of angiotensin-converting enzyme. N Engl J Med. 1986 Jan 2;314(1):61–61. doi: 10.1056/NEJM198601023140119. [DOI] [PubMed] [Google Scholar]
- Sesoko S., Kaneko Y. Cough associated with the use of captopril. Arch Intern Med. 1985 Aug;145(8):1524–1524. [PubMed] [Google Scholar]
- Simonsson B. G., Skoogh B. E., Bergh N. P., Andersson R., Svedmyr N. In vivo and in vitro effect of bradykinin on bronchial motor tone in normal subjects and patients with airways obstruction. Respiration. 1973;30(4):378–388. doi: 10.1159/000193051. [DOI] [PubMed] [Google Scholar]
- Witte P. U., Metzger H., Eckert H. G., Irmisch R. Tolerance and pharmacodynamics of the angiotensin converting enzyme inhibitor 2-[N-[(S)-1-ethoxycarbonyl-3-phenylpropyl]-L-alanyl]-(1S,3S,5S)-2- azabicyclo[3.3.0]octane-3-carboxylic acid (Hoe 498) in healthy volunteers. Arzneimittelforschung. 1984;34(10B):1448–1451. [PubMed] [Google Scholar]