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. 1987 Mar;23(3):311–315. doi: 10.1111/j.1365-2125.1987.tb03050.x

Ranitidine and cimetidine; drug interactions with single dose and steady-state nifedipine administration.

S R Smith, M J Kendall, J Lobo, A Beerahee, D B Jack, M R Wilkins
PMCID: PMC1386229  PMID: 3567045

Abstract

The effect of ranitidine 300 mg once daily and cimetidine 800 mg once daily on the disposition of nifedipine was studied in two groups of 12 volunteers. Both investigations were placebo-controlled cross-over studies. The first group received ranitidine, cimetidine or placebo for 5 days with 20 mg nifedipine given on the 5th day. Each period was separated by 1 week. The second group received nifedipine 10 mg three times daily for 5 days together with the H2-receptor antagonist or placebo. Cimetidine produced a significant increase in the AUC of both single and steady state dosing of nifedipine. Peak nifedipine levels were significantly increased only in the chronic dose study compared to placebo. Ranitidine did not produce any significant changes in either study.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bell J. A., Gower A. J., Martin L. E., Mills E. N., Smith W. P. Interaction of H2-receptor antagonists with drug-metabolizing enzymes. Biochem Soc Trans. 1981 Feb;9(1):113–114. doi: 10.1042/bst0090113. [DOI] [PubMed] [Google Scholar]
  2. Borm P., Bast A., Frankhuijzen-Sierevogel A., Noordhoek J. Cytochrome P-450 and ethoxycoumarin-deethylation in rat gastric microsomes: induction by 3-methylcholanthrene and inhibition by cimetidine. Biochem Biophys Res Commun. 1981 Sep 30;102(2):784–790. doi: 10.1016/s0006-291x(81)80200-8. [DOI] [PubMed] [Google Scholar]
  3. Dal Negro R., Turco P., Zoccatelli O., Trevisan F., Pomart C. H2-antagonist derangement of the kinetics of sustained-release oral theophylline. Int J Clin Pharmacol Ther Toxicol. 1985 Jun;23(6):329–332. [PubMed] [Google Scholar]
  4. Gerber M. C., Tejwani G. A., Gerber N., Bianchine J. R. Drug interactions with cimetidine: an update. Pharmacol Ther. 1985;27(3):353–370. doi: 10.1016/0163-7258(85)90075-0. [DOI] [PubMed] [Google Scholar]
  5. Henry D. A., Macdonald I. A., Kitchingman G., Bell G. D., Langman M. J. Cimetidine and ranitidine: comparison of effects on hepatic drug metabolism. Br Med J. 1980 Sep 20;281(6243):775–777. doi: 10.1136/bmj.281.6243.775. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kirch W., Hoensch H., Ohnhaus E. E., Janisch H. D. Ranitidin-Nifedipin-Interaktion. Dtsch Med Wochenschr. 1984 Aug 3;109(31-32):1223–1223. [PubMed] [Google Scholar]
  7. Kirch W., Janisch H. D., Heidemann H., Rämsch K., Ohnhaus E. E. Einfluss von Cimetidin und Ranitidin auf Pharmakokinetik und antihypertensiven Effekt von Nifedipin. Dtsch Med Wochenschr. 1983 Nov 18;108(46):1757–1761. doi: 10.1055/s-2008-1069821. [DOI] [PubMed] [Google Scholar]
  8. Kleinbloesem C. H., van Brummelen P., Faber H., Danhof M., Vermeulen N. P., Breimer D. D. Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man. Biochem Pharmacol. 1984 Nov 15;33(22):3721–3724. doi: 10.1016/0006-2952(84)90165-5. [DOI] [PubMed] [Google Scholar]
  9. Mangini R. J. Cimetidine--benzodiazepine interactions. Am J Hosp Pharm. 1982 Feb;39(2):236–242. [PubMed] [Google Scholar]
  10. Pelkonen O., Puurunen J. The effect of cimetidine on in vitro and in vivo microsomal drug metabolism in the rat. Biochem Pharmacol. 1980 Nov 15;29(22):3075–3080. doi: 10.1016/0006-2952(80)90448-7. [DOI] [PubMed] [Google Scholar]
  11. Powell J. R., Donn K. H. Histamine H2-antagonist drug interactions in perspective: mechanistic concepts and clinical implications. Am J Med. 1984 Nov 19;77(5B):57–84. [PubMed] [Google Scholar]
  12. Puurunen J., Sotaniemi E., Pelkonen O. Effect of cimetidine on microsomal drug metabolism in man. Eur J Clin Pharmacol. 1980 Aug;18(2):185–187. doi: 10.1007/BF00561588. [DOI] [PubMed] [Google Scholar]
  13. Rosseel M. T., Bogaert M. G. Determination of nifedipine in human plasma by capillary gas chromatography with nitrogen detection. J Chromatogr. 1983 Nov 25;279:675–680. doi: 10.1016/s0021-9673(01)93672-6. [DOI] [PubMed] [Google Scholar]
  14. Röllinghoff W., Paumgartner G. Inhibition of drug metabolism by cimetidine in man: dependence on pretreatment microsomal liver function. Eur J Clin Invest. 1982 Oct;12(5):429–432. doi: 10.1111/j.1365-2362.1982.tb00691.x. [DOI] [PubMed] [Google Scholar]

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