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. 1987 Sep;24(3):323–328. doi: 10.1111/j.1365-2125.1987.tb03176.x

Effect of food and various antacids on the absorption of tenoxicam.

R O Day 1, S Lam 1, P Paull 1, D Wade 1
PMCID: PMC1386253  PMID: 3499163

Abstract

1 Twelve healthy volunteers received a single oral dose of tenoxicam 20 mg on six occasions separated by 3 weeks. 2 The six occasions were: fasted overnight; postprandial; fasting and 15 ml aluminium hydroxide gel; postprandial and 15 ml aluminium hydroxide gel; fasting and 15 ml aluminium and magnesium hydroxide gel; postprandial and 15 ml aluminium and magnesium hydroxide gel. 3 Twenty plasma samples were collected over 15 days following dosing with tenoxicam. 4 The following kinetic parameters for plasma tenoxicam were compared: peak concentrations, time taken to reach peak concentrations, area under the plasma concentration-time curve (AUC) and half-life of elimination. 5 Food lengthened the time taken to reach peak tenoxicam concentrations (5.82 +/- 4.6 vs 1.84 +/- 1.0 h in the fasting state; P less than 0.02) and marginally reduced the peak concentrations achieved. AUC was not affected by any of the different regimens. 6 These effects of food on tenoxicam bioavailability are unlikely to be of clinical significance during chronic dosing with the drug.

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Selected References

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  1. Ayres J. W., Weidler D. J., MacKichan J., Sakmar E., Hallmark M. R., Lemanowicz E. F., Wagner J. G. Pharmacokinetics of tolmetin with and without concomitant administration of antacid in man. Eur J Clin Pharmacol. 1977 Dec 28;12(6):421–428. doi: 10.1007/BF00561061. [DOI] [PubMed] [Google Scholar]
  2. Bird H. A., Allen J. G., Dixon J. S., Wright V. A pharmacokinetic comparison of tenoxicam in plasma and synovial fluid. Br J Rheumatol. 1985 Nov;24(4):351–356. doi: 10.1093/rheumatology/24.4.351. [DOI] [PubMed] [Google Scholar]
  3. Chernish S. M., Rubin A., Rodda B. E., Ridolfo A. S., Gruber C. M., Jr The physiological disposition of fenoprofen in man. IV. The effects of position of subject, food ingestion and antacid ingestion on the plasma levels of orally administered fenoprofen. J Med. 1972;3(4):249–257. [PubMed] [Google Scholar]
  4. Day R. O., Graham G. G., Champion G. D., Lee E. Anti-rheumatic drug interactions. Clin Rheum Dis. 1984 Aug;10(2):251–275. [PubMed] [Google Scholar]
  5. Emori H. W., Paulus H., Bluestone R., Champion G. D., Pearson C. Indomethacin serum concentrations in man. Effects of dosage, food, and antacid. Ann Rheum Dis. 1976 Aug;35(4):333–338. doi: 10.1136/ard.35.4.333. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Francis R. J., Dixon J. S., Lowe J. R., Harris P. A. The effects of food and of antacid on the single oral dose pharmacokinetics of tenoxicam. Eur J Drug Metab Pharmacokinet. 1985 Oct-Dec;10(4):309–314. doi: 10.1007/BF03189758. [DOI] [PubMed] [Google Scholar]
  7. Graham G. G., Day R. O., Champion G. D., Lee E., Newton K. Aspects of the clinical pharmacology of non-steroidal anti-inflammatory drugs. Clin Rheum Dis. 1984 Aug;10(2):229–249. [PubMed] [Google Scholar]
  8. Hobbs D. C., Twomey T. M. Piroxicam pharmacokinetics in man: aspirin and antacid interaction studies. J Clin Pharmacol. 1979 May-Jun;19(5-6):270–281. doi: 10.1002/j.1552-4604.1979.tb02480.x. [DOI] [PubMed] [Google Scholar]
  9. Hurwitz A. Antacid therapy and drug kinetics. Clin Pharmacokinet. 1977 Jul-Aug;2(4):269–280. doi: 10.2165/00003088-197702040-00003. [DOI] [PubMed] [Google Scholar]
  10. Segre E. J., Sevelius H., Varady J. Letter: Effects of antacids on naproxen absorption. N Engl J Med. 1974 Sep 12;291(11):582–583. doi: 10.1056/NEJM197409122911115. [DOI] [PubMed] [Google Scholar]
  11. Verbeeck R., Tjandramaga T. B., Mullie A., Verbesselt R., Verberckmoes R., de Schepper P. J. Biotransformation of diflunisal and renal excretion of its glucuronides in renal insufficiency. Br J Clin Pharmacol. 1979 Mar;7(3):273–282. doi: 10.1111/j.1365-2125.1979.tb00932.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Verbeeck R., Tjandramaga T. B., Mullie A., Verbesselt R., de Schepper P. J. Effect of aluminum hydroxide on diflunisal absorption. Br J Clin Pharmacol. 1979 May;7(5):519–522. doi: 10.1111/j.1365-2125.1979.tb00997.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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