Abstract
Topical 1% indomethacin had no effect on chronic stable plaque psoriasis in an open controlled study using subjective clinical scores nor in a randomised double-blind inert base controlled study using both subjective and objective measurements of lesional response; nor did it initiate or affect the development of psoriasis after cold injury. Previous studies are reviewed and it is concluded that the evidence does not support the hypothesis which relates psoriasis to eicosanoids produced by lipoxygenase activity.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Camp R., Jones R. R., Brain S., Woollard P., Greaves M. Production of intraepidermal microabscesses by topical application of leukotriene B4. J Invest Dermatol. 1984 Feb;82(2):202–204. doi: 10.1111/1523-1747.ep12259945. [DOI] [PubMed] [Google Scholar]
- Ellis C. N., Fallon J. D., Kang S., Vanderveen E. E., Voorhees J. J. Topical application of nonsteroidal anti-inflammatory drugs prevents vehicle-induced improvement of psoriasis. J Am Acad Dermatol. 1986 Jan;14(1):39–43. doi: 10.1016/s0190-9622(86)70004-2. [DOI] [PubMed] [Google Scholar]
- FARBER E. M., ROTH R. J., ASCHHEIM E., EDDY D. D., EPINETTE W. W. ROLE OF TRAUMA IN ISOMORPHIC RESPONSE IN PSORIASIS. Arch Dermatol. 1965 Mar;91:246–251. doi: 10.1001/archderm.1965.01600090054011. [DOI] [PubMed] [Google Scholar]
- Farr P. M., Diffey B. L. A quantitative study of the effect of topical indomethacin on cutaneous erythema induced by UVB and UVC radiation. Br J Dermatol. 1986 Oct;115(4):453–466. doi: 10.1111/j.1365-2133.1986.tb06240.x. [DOI] [PubMed] [Google Scholar]
- Katayama H., Kawada A. Exacerbation of psoriasis induced by indomethacin. J Dermatol. 1981 Aug;8(4):323–327. doi: 10.1111/j.1346-8138.1981.tb02551.x. [DOI] [PubMed] [Google Scholar]
- Kern A. B. Indomethacin for psoriasis. Arch Dermatol. 1966 Feb;93(2):239–240. [PubMed] [Google Scholar]
- Lawrence C. M., Shuster S. Mechanism of anthralin inflammation. I. Dissociation of response to clobetasol and indomethacin. Br J Dermatol. 1985 Jul;113(1):107–115. doi: 10.1111/j.1365-2133.1985.tb02050.x. [DOI] [PubMed] [Google Scholar]
- Marsden J. R., Coburn P. R., Marks J., Shuster S. Measurement of the response of psoriasis to short-term application of anthralin. Br J Dermatol. 1983 Aug;109(2):209–218. doi: 10.1111/j.1365-2133.1983.tb07083.x. [DOI] [PubMed] [Google Scholar]
- Maurice P. D., Allen B. R., Heptinstall S., Bather P. C. Arachidonic acid metabolism by peripheral blood cells in psoriasis. Br J Dermatol. 1986 May;114(5):553–566. doi: 10.1111/j.1365-2133.1986.tb04062.x. [DOI] [PubMed] [Google Scholar]