Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1987 Jul;24(1):43–50. doi: 10.1111/j.1365-2125.1987.tb03134.x

Effects of triprolidine and dipipanone in the cold induced pain test, and the central nervous system of healthy volunteers.

A Telekes, R L Holland, D A Withington, A W Peck
PMCID: PMC1386278  PMID: 3620284

Abstract

1 Twelve healthy volunteers took part in a study of the interaction between the antihistamine triprolidine and the opioid dipipanone in the cold induced pain (CP) test and tests of sedation. They received placebo, triprolidine 2.5 mg, dipipanone 8 mg or the combination of the two active treatments according to a double-blind, randomised, balanced, crossover design. 2 Antihistamine activity was demonstrated by triprolidine reducing the size of wheals and flares produced by intradermal histamine 1.6 micrograms. However, triprolidine produced no analgesia in the CP test, nor did it enhance the analgesia produced by dipipanone alone. 3 Neither treatment alone produced statistically significant sedation, assessed by visual analogue scales (VAS), side effect check list, body sway and reaction times. However, the combination did cause significant sedation. 4 Dipipanone reduced pupil size, depressed respiration, and decreased salivation. Triprolidine had no effects on pupil size and respiration, but reduced salivation slightly. It was concluded that histaminergic (H1) mechanisms are unlikely to be involved in pain produced by cold.

Full text

PDF
43

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellville J. W., Dorey F., Capparell D., Knox V., Bauer R. O. Analgesic effects of hydroxyzine compared to morphine in man. J Clin Pharmacol. 1979 May-Jun;19(5-6):290–296. doi: 10.1002/j.1552-4604.1979.tb02482.x. [DOI] [PubMed] [Google Scholar]
  2. Bluhm R., Zsigmond E. K., Winnie A. P. Potentiation of opioid analgesia by H1 and H2 antagonists. Life Sci. 1982 Sep 20;31(12-13):1229–1232. doi: 10.1016/0024-3205(82)90349-6. [DOI] [PubMed] [Google Scholar]
  3. Bye C. E., Clubley M., Henson T., Peck A. W., Smith S. A., Smith S. E. Changes in the human light reflex as a measure of the anticholinergic effects of drugs. A comparison with other measures. Eur J Clin Pharmacol. 1979 Feb 19;15(1):21–25. doi: 10.1007/BF00563554. [DOI] [PubMed] [Google Scholar]
  4. Cohen A. F., Hamilton M., Philipson R., Peck A. W. The acute effects of acrivastine (BW825C), a new antihistamine, compared with triprolidine on measures of central nervous system performance and subjective effects. Clin Pharmacol Ther. 1985 Oct;38(4):381–386. doi: 10.1038/clpt.1985.191. [DOI] [PubMed] [Google Scholar]
  5. Garcia de Jalon P. D., Harrison F. J., Johnson K. I., Kozma C., Schnelle K. A modified cold stimulation technique for the evaluation of analgesic activity in human volunteers. Pain. 1985 Jun;22(2):183–189. doi: 10.1016/0304-3959(85)90178-2. [DOI] [PubMed] [Google Scholar]
  6. HOUGS W., SKOUBY A. P. The analgetic action of analgetics, antihistaminics and chlorpromazine on volunteers. Acta Pharmacol Toxicol (Copenh) 1957;13(4):405–409. doi: 10.1111/j.1600-0773.1957.tb00276.x. [DOI] [PubMed] [Google Scholar]
  7. Hamilton M., Bush M., Bye C., Peck A. W. A comparison of triprolidine and cyclizine on histamine (H1) antagonism, subjective effects and performance tests in man. Br J Clin Pharmacol. 1982 Mar;13(3):441–444. doi: 10.1111/j.1365-2125.1982.tb01399.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Hough L. B., Su K. L., Goldschmidt R. C., Khandelwal J. K., Newton M. V., Glick S. D. No evidence for histamine-mediated morphine analgesia. Neuropharmacology. 1984 Jun;23(6):705–709. doi: 10.1016/0028-3908(84)90169-2. [DOI] [PubMed] [Google Scholar]
  9. Mattila M. J., Saarnivaara L. Modification by antihistaminic drugs of the morphine analgesia in rabbits. Ann Med Exp Biol Fenn. 1968;46(1):72–77. [PubMed] [Google Scholar]
  10. Morichi R., Pepeu G. A study of the potentiation of morphine antinociception by hydroxyzine in the rat [proceedings]. Br J Pharmacol. 1978 Mar;62(3):391P–392P. [PMC free article] [PubMed] [Google Scholar]
  11. Peck A. W., Fowle A. S., Bye C. A comparison of triprolidine and clemastine on histamine antagonism and performance tests in man: implications for the mechanism of drug induced drowsiness. Eur J Clin Pharmacol. 1975 Aug 14;8(6):455–463. doi: 10.1007/BF00562321. [DOI] [PubMed] [Google Scholar]
  12. Posner J., Telekes A., Crowley D., Phillipson R., Peck A. W. Effects of an opiate on cold-induced pain and the CNS in healthy volunteers. Pain. 1985 Sep;23(1):73–82. doi: 10.1016/0304-3959(85)90232-5. [DOI] [PubMed] [Google Scholar]
  13. Read D. J. A clinical method for assessing the ventilatory response to carbon dioxide. Australas Ann Med. 1967 Feb;16(1):20–32. doi: 10.1111/imj.1967.16.1.20. [DOI] [PubMed] [Google Scholar]
  14. Rumore M. M., Schlichting D. A. Clinical efficacy of antihistaminics as analgesics. Pain. 1986 Apr;25(1):7–22. doi: 10.1016/0304-3959(86)90004-7. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES