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. 1987 Jul;24(1):110–113. doi: 10.1111/j.1365-2125.1987.tb03146.x

Lack of inhibitory effect of metronidazole on theophylline disposition in healthy subjects.

G I Adebayo, A F Mabadeje
PMCID: PMC1386290  PMID: 3620280

Abstract

The effect of metronidazole, at a dose of 1.2 g daily, on theophylline disposition was studied in 10 healthy adult volunteers. Neither theophylline half-life, volume of distribution nor total body clearance was altered by the anti-microbial. It is concluded that metronidazole does not impair theophylline metabolism despite the fact that it is a substituted imidazole.

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Selected References

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