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. 1987 Oct;24(4):503–510. doi: 10.1111/j.1365-2125.1987.tb03204.x

Inhibition of artificially induced cough in man by bronchodilators.

R Lowry 1, T Higenbottam 1, T Johnson 1, D Godden 1
PMCID: PMC1386313  PMID: 3689630

Abstract

1. The antitussive properties of bronchodilators were evaluated in a total of 47 normal volunteers. 2. Cough was induced by inhalation of ultrasonically nebulized solutions of distilled water and hypotonic saline. 3. Inhaled fenoterol hydrobromide (360 micrograms; 20 volunteers) and inhaled ipratropium bromide (72 micrograms; 14 volunteers) both significantly reduced couch compared with placebo (P less than 0.01). Oral salbutamol sulphate (4 mg; 11 volunteers) and oral pirenzepine hydrochloride (50 mg; 14 volunteers) had lesser effects. 4. Cough inhibition correlated with a small but statistically significant degree of bronchodilatation as measured by specific airway conductance (sGaw) and forced expiratory volume in one second (FEV1) in six normal subjects studied with each treatment in a placebo controlled, double blind study (r = 0.67, P less than 0.001). 5. Small reductions in airway tone are associated with a reduced cough response elicited by inhaled ultrasonically nebulized distilled water.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Al-Bazzaz F. J., Cheng E. Effect of catecholamines on ion transport in dog tracheal epithelium. J Appl Physiol Respir Environ Exerc Physiol. 1979 Aug;47(2):397–403. doi: 10.1152/jappl.1979.47.2.397. [DOI] [PubMed] [Google Scholar]
  2. Al-Bazzaz F. J. Role of cyclic AMP in regulation of chloride secretion by canine tracheal mucosa. Am Rev Respir Dis. 1981 Mar;123(3):295–298. doi: 10.1164/arrd.1981.123.3.295. [DOI] [PubMed] [Google Scholar]
  3. BICKERMAN H. A., BARACH A. L. The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents. Am J Med Sci. 1954 Aug;228(2):156–163. doi: 10.1097/00000441-195408000-00005. [DOI] [PubMed] [Google Scholar]
  4. Banner A. S., Green J., O'Connor M. Relation of respiratory water loss to coughing after exercise. N Engl J Med. 1984 Oct 4;311(14):883–886. doi: 10.1056/NEJM198410043111404. [DOI] [PubMed] [Google Scholar]
  5. Barnes P. J., Cuss F. M., Palmer J. B. The effect of airway epithelium on smooth muscle contractility in bovine trachea. Br J Pharmacol. 1985 Nov;86(3):685–691. doi: 10.1111/j.1476-5381.1985.tb08946.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Belcher N., Rees P. J. Effects of pholcodine and salbutamol on citric acid induced cough in normal subjects. Thorax. 1986 Jan;41(1):74–75. doi: 10.1136/thx.41.1.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Bellville J. W., Seed J. C. A comparison of the respiratory depressant effects of dextropropoyphene and codeine in man. Clin Pharmacol Ther. 1968 Jul-Aug;9(4):428–434. doi: 10.1002/cpt196894428. [DOI] [PubMed] [Google Scholar]
  8. Boggs D. F., Bartlett D., Jr Chemical specificity of a laryngeal apneic reflex in puppies. J Appl Physiol Respir Environ Exerc Physiol. 1982 Aug;53(2):455–462. doi: 10.1152/jappl.1982.53.2.455. [DOI] [PubMed] [Google Scholar]
  9. Boushey H. A., Richardson P. S., Widdicombe J. G., Wise J. C. The response of laryngeal afferent fibres to mechanical and chemical stimuli. J Physiol. 1974 Jul;240(1):153–175. doi: 10.1113/jphysiol.1974.sp010605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Chadha T. S., Birch S., Allegra L., Sackner M. A. Effects of ultrasonically nebulized distilled water on respiratory resistance and breathing pattern in normals and asthmatics. Bull Eur Physiopathol Respir. 1984 May-Jun;20(3):257–262. [PubMed] [Google Scholar]
  11. Corrao W. M., Braman S. S., Irwin R. S. Chronic cough as the sole presenting manifestation of bronchial asthma. N Engl J Med. 1979 Mar 22;300(12):633–637. doi: 10.1056/NEJM197903223001201. [DOI] [PubMed] [Google Scholar]
  12. Dixon M., Jackson D. M., Richards I. M. The action of sodium cromoglycate on 'C' fibre endings in the dog lung. Br J Pharmacol. 1980 Sep;70(1):11–13. doi: 10.1111/j.1476-5381.1980.tb10898.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Duffey M. E., Hainau B., Ho S., Bentzel C. J. Regulation of epithelial tight junction permeability by cyclic AMP. Nature. 1981 Dec 3;294(5840):451–453. doi: 10.1038/294451a0. [DOI] [PubMed] [Google Scholar]
  14. Ellul-Micallef R. Effect of terbutaline sulphate in chronic "allergic" cough. Br Med J (Clin Res Ed) 1983 Oct 1;287(6397):940–943. doi: 10.1136/bmj.287.6397.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Empey D. W., Laitinen L. A., Jacobs L., Gold W. M., Nadel J. A. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976 Feb;113(2):131–139. doi: 10.1164/arrd.1976.113.2.131. [DOI] [PubMed] [Google Scholar]
  16. Erlij D., Martínez-Palomo A. Opening of tight junctions in frog skin by hypertonic urea solutions. J Membr Biol. 1972;9(3):229–240. [PubMed] [Google Scholar]
  17. Eschenbacher W. L., Boushey H. A., Sheppard D. Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone. Am Rev Respir Dis. 1984 Feb;129(2):211–215. [PubMed] [Google Scholar]
  18. Ferreira K. T., Hill B. S. The effect of low external pH on properties of the paracellular pathway and junctional structure in isolated frog skin. J Physiol. 1982 Nov;332:59–67. doi: 10.1113/jphysiol.1982.sp014400. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Flavahan N. A., Aarhus L. L., Rimele T. J., Vanhoutte P. M. Respiratory epithelium inhibits bronchial smooth muscle tone. J Appl Physiol (1985) 1985 Mar;58(3):834–838. doi: 10.1152/jappl.1985.58.3.834. [DOI] [PubMed] [Google Scholar]
  20. Frizzell R. A., Field M., Schultz S. G. Sodium-coupled chloride transport by epithelial tissues. Am J Physiol. 1979 Jan;236(1):F1–F8. doi: 10.1152/ajprenal.1979.236.1.F1. [DOI] [PubMed] [Google Scholar]
  21. Godden D. J., Borland C., Lowry R., Higenbottam T. W. Chemical specificity of coughing in man. Clin Sci (Lond) 1986 Mar;70(3):301–306. doi: 10.1042/cs0700301. [DOI] [PubMed] [Google Scholar]
  22. Hanácek J., Davies A., Widdicombe J. G. Influence of lung stretch receptors on the cough reflex in rabbits. Respiration. 1984;45(3):161–168. doi: 10.1159/000194614. [DOI] [PubMed] [Google Scholar]
  23. Heel R. C., Brogden R. N., Speight T. M., Avery G. S. Fenoterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1978 Jan;15(1):3–32. doi: 10.2165/00003495-197815010-00002. [DOI] [PubMed] [Google Scholar]
  24. Higenbottam T. Cough induced by changes of ionic composition of airway surface liquid. Bull Eur Physiopathol Respir. 1984 Nov-Dec;20(6):553–562. [PubMed] [Google Scholar]
  25. Irwin R. S., Corrao W. M., Pratter M. R. Chronic persistent cough in the adult: the spectrum and frequency of causes and successful outcome of specific therapy. Am Rev Respir Dis. 1981 Apr;123(4 Pt 1):413–417. doi: 10.1164/arrd.1981.123.4.413. [DOI] [PubMed] [Google Scholar]
  26. Jeffery P., Reid L. Intra-epithelial nerves in normal rat airways: a quantitative electron microscopic study. J Anat. 1973 Jan;114(Pt 1):35–45. [PMC free article] [PubMed] [Google Scholar]
  27. Kennedy M. C., Simpson W. T. Human pharmacological and clinical studies on salbutamol: a specific beta-adrenergic bronchodilator. Br J Dis Chest. 1969 Jul;63(3):165–174. doi: 10.1016/s0007-0971(69)80014-8. [DOI] [PubMed] [Google Scholar]
  28. Man S. F., Adams G. K., 3rd, Proctor D. F. Effects of temperature, relative humidity, and mode of breathing on canine airway secretions. J Appl Physiol Respir Environ Exerc Physiol. 1979 Feb;46(2):205–210. doi: 10.1152/jappl.1979.46.2.205. [DOI] [PubMed] [Google Scholar]
  29. Marin M. G., Davis B., Nadel J. A. Effect of acetylcholine on Cl- and Na+ fluxes across dog tracheal epithelium in vitro. Am J Physiol. 1976 Nov;231(5 Pt 1):1546–1549. doi: 10.1152/ajplegacy.1976.231.5.1546. [DOI] [PubMed] [Google Scholar]
  30. Mitsuhashi M., Tokuyama K., Morikawa A., Kuroume T., Tazawa M. Does disodium cromoglycate stabilise cough receptors on human airways? Lancet. 1984 Mar 10;1(8376):576–576. doi: 10.1016/s0140-6736(84)90985-1. [DOI] [PubMed] [Google Scholar]
  31. Pakes G. E., Brogden R. N., Heel R. C., Speight T. M., Avery G. S. Ipratropium bromide: a review of its pharmacological properties and therapeutic efficacy in asthma and chronic bronchitis. Drugs. 1980 Oct;20(4):237–266. doi: 10.2165/00003495-198020040-00001. [DOI] [PubMed] [Google Scholar]
  32. Phipps R. J., Williams I. P., Richardson P. S., Pell J., Pack R. J., Wright N. Sympathomimetic drugs stimulate the output of secretory glycoproteins from human bronchi in vitro. Clin Sci (Lond) 1982 Jul;63(1):23–28. doi: 10.1042/cs0630023. [DOI] [PubMed] [Google Scholar]
  33. Pounsford J. C., Birch M. J., Saunders K. B. Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects. Thorax. 1985 Sep;40(9):662–667. doi: 10.1136/thx.40.9.662. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. Sheppard D., Rizk N. W., Boushey H. A., Bethel R. A. Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am Rev Respir Dis. 1983 Jun;127(6):691–694. doi: 10.1164/arrd.1983.127.6.691. [DOI] [PubMed] [Google Scholar]
  35. Shoemaker R. L., Makhlouf G. M., Sachs G. Action of cholinergic drugs on Necturus gastric mucosa. Am J Physiol. 1970 Oct;219(4):1056–1060. doi: 10.1152/ajplegacy.1970.219.4.1056. [DOI] [PubMed] [Google Scholar]
  36. Simonsson B. G., Jacobs F. M., Nadel J. A. Role of autonomic nervous system and the cough reflex in the increased responsiveness of airways in patients with obstructive airway disease. J Clin Invest. 1967 Nov;46(11):1812–1818. doi: 10.1172/JCI105671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  37. Stockbrügger R., Jaup B., Hammer R., Dotevall G. Inhibition of gastric acid secretion by pirenzepine (LS 519) in man. Scand J Gastroenterol. 1979;14(5):615–620. doi: 10.3109/00365527909181399. [DOI] [PubMed] [Google Scholar]
  38. WIDDICOMBE J. G. The activity of pulmonary stretch receptors during bronchoconstriction, pulmonary oedema, atelectasis and breathing against a resistance. J Physiol. 1961 Dec;159:436–450. doi: 10.1113/jphysiol.1961.sp006819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Wade J. B., Revel J. P., DiScala V. A. Effect of osmotic gradients on intercellular junctions of the toad bladder. Am J Physiol. 1973 Feb;224(2):407–415. doi: 10.1152/ajplegacy.1973.224.2.407. [DOI] [PubMed] [Google Scholar]
  40. Widdicombe J. G., Sterling G. M. The autonomic nervous system and breathing. Arch Intern Med. 1970 Aug;126(2):311–329. [PubMed] [Google Scholar]
  41. Yeates D. B., Pitt B. R., Spektor D. M., Karron G. A., Albert R. E. Coordination of mucociliary transport in human trachea and intrapulmonary airways. J Appl Physiol Respir Environ Exerc Physiol. 1981 Nov;51(5):1057–1064. doi: 10.1152/jappl.1981.51.5.1057. [DOI] [PubMed] [Google Scholar]

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