Abstract
The pharmacokinetics of theophylline (i.v. aminophylline 250 mg) were studied in a balanced, double-blind crossover following the administration of oral temelastine (100 mg) or placebo, twice daily for 7 days, to 10 normal volunteers. Comparison of volumes of distribution, elimination rate constants, elimination half-lives and areas under the plasma concentration-time curve indicated that temelastine had no significant effect on theophylline pharmacokinetics.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brown E. A., Griffiths R., Harvey C. A., Owen D. A. Pharmacological studies with SK&F 93944 (temelastine), a novel histamine H1-receptor antagonist with negligible ability to penetrate the central nervous system. Br J Pharmacol. 1986 Mar;87(3):569–578. doi: 10.1111/j.1476-5381.1986.tb10199.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Clark D. R. Theophylline assay by liquid chromatography: removal of acetazolamide interference. Clin Chem. 1979 Jun;25(6):1183–1183. [PubMed] [Google Scholar]
- Rogers S. J., Doyle E., McCulla B. A., Lee R. M. Measurement of concentrations of the histamine H1 receptor antagonist temelastine in biological fluids. J Pharm Sci. 1986 Aug;75(8):813–814. doi: 10.1002/jps.2600750819. [DOI] [PubMed] [Google Scholar]
- Yamaoka K., Tanigawara Y., Nakagawa T., Uno T. A pharmacokinetic analysis program (multi) for microcomputer. J Pharmacobiodyn. 1981 Nov;4(11):879–885. doi: 10.1248/bpb1978.4.879. [DOI] [PubMed] [Google Scholar]