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. 1988 Mar;25(3):397–400. doi: 10.1111/j.1365-2125.1988.tb03319.x

Selective inhibitory effects of nifedipine and verapamil on oxidative metabolism: effects on theophylline.

R A Robson 1, J O Miners 1, D J Birkett 1
PMCID: PMC1386365  PMID: 3358901

Abstract

Nine healthy male volunteers were studied to assess the possibility of an interaction between theophylline and nifedipine or verapamil using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without nifedipine 20 mg 12 hourly and verapamil 80 mg 8 hourly. Nifedipine treatment reduced mean total theophylline clearance by 9%, due to decreased clearances via 1- and 3-demethylation. Verapamil treatment reduced mean total theophylline clearance by 14%, due to decreased clearances via 1- and 3-demethylation and 8-hydroxylation. Verapamil and nifedipine at usual clinical doses are unlikely to cause clinically significant changes in theophylline disposition.

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Selected References

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  1. Bauer L. A., Stenwall M., Horn J. R., Davis R., Opheim K., Greene L. Changes in antipyrine and indocyanine green kinetics during nifedipine, verapamil, and diltiazem therapy. Clin Pharmacol Ther. 1986 Aug;40(2):239–242. doi: 10.1038/clpt.1986.169. [DOI] [PubMed] [Google Scholar]
  2. Birkett D. J., Dahlqvist R., Miners J. O., Lelo A., Billing B. Comparison of theophylline and theobromine metabolism in man. Drug Metab Dispos. 1985 Nov-Dec;13(6):725–728. [PubMed] [Google Scholar]
  3. Birkett D. J., Miners J. O., Attwood J. Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interaction. Br J Clin Pharmacol. 1983 May;15(5):567–569. doi: 10.1111/j.1365-2125.1983.tb02093.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Burnakis T. G., Seldon M., Czaplicki A. D. Increased serum theophylline concentrations secondary to oral verapamil. Clin Pharm. 1983 Sep-Oct;2(5):458–461. [PubMed] [Google Scholar]
  5. Garty M., Cohen E., Mazar A., Ilfeld D. N., Spitzer S., Rosenfeld J. B. Effect of nifedipine and theophylline in asthma. Clin Pharmacol Ther. 1986 Aug;40(2):195–198. doi: 10.1038/clpt.1986.163. [DOI] [PubMed] [Google Scholar]
  6. Jackson S. H., Shah K., Debbas N. M., Johnston A., Peverel-Cooper C. A., Turner P. The interaction between i.v. theophylline and chronic oral dosing with slow release nifedipine in volunteers. Br J Clin Pharmacol. 1986 Apr;21(4):389–392. doi: 10.1111/j.1365-2125.1986.tb05212.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Macphee G. J., McInnes G. T., Thompson G. G., Brodie M. J. Verapamil potentiates carbamazepine neurotoxicity: a clinically important inhibitory interaction. Lancet. 1986 Mar 29;1(8483):700–703. doi: 10.1016/s0140-6736(86)91099-8. [DOI] [PubMed] [Google Scholar]
  8. Rumiantsev D. O., Piotrovskii V. K., Riabokon O. S., Slastnikova I. D., Kokurina E. V., Metelitsa V. I. The effect of oral verapamil therapy on antipyrine clearance. Br J Clin Pharmacol. 1986 Nov;22(5):606–609. doi: 10.1111/j.1365-2125.1986.tb02942.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Wing L. M., Miners J. O., Lillywhite K. J. Verapamil disposition--effects of sulphinpyrazone and cimetidine. Br J Clin Pharmacol. 1985 Mar;19(3):385–391. doi: 10.1111/j.1365-2125.1985.tb02658.x. [DOI] [PMC free article] [PubMed] [Google Scholar]

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