Abstract
The distribution of antiarrhythmic drugs in human tissues may yield a better understanding of their therapeutic action and side effects. We report tissue distribution of flecainide in a patient who died suddenly while being treated chronically with the drug. Lungs showed the highest concentration of flecainide (143 micrograms g-1 wet tissue); liver, kidney and heart, in decreasing order, have good affinity for the drug. Flecainide was present also in the central nervous system in lower concentrations. The lowest concentration was found in the adipose tissue.
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Selected References
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- Chang S. F., Miller A. M., Fox J. M., Welscher T. M. Application of a bonded-phase extraction column for rapid sample preparation of flecainide from human plasma for high-performance liquid chromatographic analysis--fluorescence or ultraviolet detection. Ther Drug Monit. 1984;6(1):105–111. doi: 10.1097/00007691-198403000-00017. [DOI] [PubMed] [Google Scholar]
- Holmes B., Heel R. C. Flecainide. A preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1985 Jan;29(1):1–33. doi: 10.2165/00003495-198529010-00001. [DOI] [PubMed] [Google Scholar]
- Latini R., Marchi S., Riva E., Cavalli A., Cazzaniga M. G., Maggioni A. P., Volpi A. Distribution of propafenone and its active metabolite, 5-hydroxypropafenone, in human tissues. Am Heart J. 1987 Mar;113(3):843–844. doi: 10.1016/0002-8703(87)90735-6. [DOI] [PubMed] [Google Scholar]
- Latini R., Tognoni G., Kates R. E. Clinical pharmacokinetics of amiodarone. Clin Pharmacokinet. 1984 Mar-Apr;9(2):136–156. doi: 10.2165/00003088-198409020-00002. [DOI] [PubMed] [Google Scholar]
- Piovan D., Padrini R., Furlanut M., Moretto R., Ferrari M. Plasma and tissue levels of flecainide in rats. Pharmacol Res Commun. 1986 Aug;18(8):739–745. doi: 10.1016/0031-6989(86)90115-3. [DOI] [PubMed] [Google Scholar]