Abstract
Twelve male volunteers were studied after a single oral dose of 20 mg omeprazole given as enteric-coated granules with and without concomitant administration of 10 ml of a potent liquid antacid (buffering capacity 56.6 mmol 10 ml-1) under fasting conditions. No statistically significant differences were detected in median Cmax (0.41 approximately equal to 0.53 mumol l-1), the geometric mean AUC (0.80 approximately equal to 0.81 mumol l-1 h) or median tmax (1.25 h), with and without antacid.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Fellenius E., Berglindh T., Sachs G., Olbe L., Elander B., Sjöstrand S. E., Wallmark B. Substituted benzimidazoles inhibit gastric acid secretion by blocking (H+ + K+)ATPase. Nature. 1981 Mar 12;290(5802):159–161. doi: 10.1038/290159a0. [DOI] [PubMed] [Google Scholar]
- Howden C. W., Forrest J. A., Reid J. L. Effects of single and repeated doses of omeprazole on gastric acid and pepsin secretion in man. Gut. 1984 Jul;25(7):707–710. doi: 10.1136/gut.25.7.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Howden C. W., Meredith P. A., Forrest J. A., Reid J. L. Oral pharmacokinetics of omeprazole. Eur J Clin Pharmacol. 1984;26(5):641–643. doi: 10.1007/BF00543502. [DOI] [PubMed] [Google Scholar]
- Lagerström P. O., Persson B. A. Determination of omeprazole and metabolites in plasma and urine by liquid chromatography. J Chromatogr. 1984 Aug 10;309(2):347–356. doi: 10.1016/0378-4347(84)80042-0. [DOI] [PubMed] [Google Scholar]
- Lind T., Cederberg C., Ekenved G., Haglund U., Olbe L. Effect of omeprazole--a gastric proton pump inhibitor--on pentagastrin stimulated acid secretion in man. Gut. 1983 Apr;24(4):270–276. doi: 10.1136/gut.24.4.270. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pilbrant A., Cederberg C. Development of an oral formulation of omeprazole. Scand J Gastroenterol Suppl. 1985;108:113–120. doi: 10.3109/00365528509095824. [DOI] [PubMed] [Google Scholar]
- Prichard P. J., Yeomans N. D., Mihaly G. W., Jones D. B., Buckle P. J., Smallwood R. A., Louis W. J. Omeprazole: a study of its inhibition of gastric pH and oral pharmacokinetics after morning or evening dosage. Gastroenterology. 1985 Jan;88(1 Pt 1):64–69. doi: 10.1016/s0016-5085(85)80133-5. [DOI] [PubMed] [Google Scholar]