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. 1988 Jun;25(6):725–732. doi: 10.1111/j.1365-2125.1988.tb05259.x

The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.

R F Jeffrey 1, T M Macdonald 1, J Brown 1, P W Rae 1, M R Lee 1
PMCID: PMC1386450  PMID: 2849472

Abstract

1. The effect of oral lithium on the renal response to gamma-L-glutamyl-L-dopa (gludopa, 25 micrograms kg-1 min-1) was investigated in seven normal males. 2. Gludopa at this dose produced an 800-fold increase in urine dopamine excretion. It was natriuretic and suppressed plasma renin activity without altering blood pressure and pulse. 3. Lithium alone increased sodium excretion and stimulated plasma renin activity. However, it abolished the natriuresis produced by gludopa. 4. Gludopa did not significantly affect lithium clearance. 5. This study suggests that lithium interacts with dopamine at the proximal tubule and that the lithium clearance method is not suitable for investigating dopaminergic mechanisms in the kidney.

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Selected References

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  1. ALBERT Z., ORLOWSKI M., SZEWCZUK A. Histochemical demonstration of gamma-glutamyl transpeptidase. Nature. 1961 Aug 19;191:767–768. doi: 10.1038/191767a0. [DOI] [PubMed] [Google Scholar]
  2. Aperia A., Bertorello A., Seri I. Dopamine causes inhibition of Na+-K+-ATPase activity in rat proximal convoluted tubule segments. Am J Physiol. 1987 Jan;252(1 Pt 2):F39–F45. doi: 10.1152/ajprenal.1987.252.1.F39. [DOI] [PubMed] [Google Scholar]
  3. Baer L., Platman S. R., Kassir S., Fieve R. R. Mechanisms of renal lithium handling and their relationship to mineralocorticoids: a dissociation between sodium and lithium ions. J Psychiatr Res. 1971 Jun;8(2):91–105. doi: 10.1016/0022-3956(71)90011-2. [DOI] [PubMed] [Google Scholar]
  4. Bello-Reuss E., Higashi Y., Kaneda Y. Dopamine decreases fluid reabsorption in straight portions of rabbit proximal tubule. Am J Physiol. 1982 Jun;242(6):F634–F640. doi: 10.1152/ajprenal.1982.242.6.F634. [DOI] [PubMed] [Google Scholar]
  5. Felder R. A., Blecher M., Calcagno P. L., Jose P. A. Dopamine receptors in the proximal tubule of the rabbit. Am J Physiol. 1984 Sep;247(3 Pt 2):F499–F505. doi: 10.1152/ajprenal.1984.247.3.F499. [DOI] [PubMed] [Google Scholar]
  6. Forrest J. N., Jr, Cohen A. D., Torretti J., Himmelhoch J. M., Epstein F. H. On the mechanism of lithium-induced diabetes insipidus in man and the rat. J Clin Invest. 1974 Apr;53(4):1115–1123. doi: 10.1172/JCI107649. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Frederickson E. D., Bradley T., Goldberg L. I. Blockade of renal effects of dopamine in the dog by the DA1 antagonist SCH 23390. Am J Physiol. 1985 Aug;249(2 Pt 2):F236–F240. doi: 10.1152/ajprenal.1985.249.2.F236. [DOI] [PubMed] [Google Scholar]
  8. Goldstein M., Fuxe K., Hökfelt T. Characterization and tissue localization of catecholamine synthesizing enzymes. Pharmacol Rev. 1972 Jun;24(2):293–309. [PubMed] [Google Scholar]
  9. Guerri C., Ribelles M., Grisolía S. Effects of lithium, and lithium and alcohol administration on (Na + K)-ATPase. Biochem Pharmacol. 1981 Jan 1;30(1):25–30. doi: 10.1016/0006-2952(81)90280-x. [DOI] [PubMed] [Google Scholar]
  10. Haber E., Koerner T., Page L. B., Kliman B., Purnode A. Application of a radioimmunoassay for angiotensin I to the physiologic measurements of plasma renin activity in normal human subjects. J Clin Endocrinol Metab. 1969 Oct;29(10):1349–1355. doi: 10.1210/jcem-29-10-1349. [DOI] [PubMed] [Google Scholar]
  11. Hagege J., Richet G. Proximal tubule dopamine histofluorescence in renal slices incubated with L-dopa. Kidney Int. 1985 Jan;27(1):3–8. doi: 10.1038/ki.1985.2. [DOI] [PubMed] [Google Scholar]
  12. Hecht B., Kashgarian M., Forrest J. N., Jr, Hayslett J. P. Micropuncture study on the effects of lithium on proximal and distal tubule function in the rat kidney. Pflugers Arch. 1978 Oct 18;377(1):69–74. doi: 10.1007/BF00584376. [DOI] [PubMed] [Google Scholar]
  13. Jeffrey R. F., Macdonald T. M., Rutter M., Freestone S., Brown J., Samson R. R., Lee M. R. The effect of intravenous frusemide on urine dopamine in normal volunteers: studies with indomethacin and carbidopa. Clin Sci (Lond) 1987 Aug;73(2):151–157. doi: 10.1042/cs0730151. [DOI] [PubMed] [Google Scholar]
  14. Murphy D. L., Goodwin F. K., Bunney W. E., Jr Aldosterone and sodium response to lithium administration in man. Lancet. 1969 Aug 30;2(7618):458–461. doi: 10.1016/s0140-6736(69)90166-4. [DOI] [PubMed] [Google Scholar]
  15. Myers J. B., Morgan T. O., Carney S. L., Ray C. Effects of lithium on the kidney. Kidney Int. 1980 Nov;18(5):601–608. doi: 10.1038/ki.1980.178. [DOI] [PubMed] [Google Scholar]
  16. Nakajima T., Naitoh F., Kuruma I. Dopamine-sensitive adenylate cyclase in the rat kidney particulate preparation. Eur J Pharmacol. 1977 Jan 21;41(2):163–169. doi: 10.1016/0014-2999(77)90205-9. [DOI] [PubMed] [Google Scholar]
  17. Nally J. V., Rutecki G. W., Ferris T. F. The acute effect of lithium on renal renin and prostaglandin E synthesis in the dog. Circ Res. 1980 Jun;46(6):739–744. doi: 10.1161/01.res.46.6.739. [DOI] [PubMed] [Google Scholar]
  18. O'Reilly D. S., Fraser W. D., Penney M. D., Logue F. C., Cowan R. A., Williams B. C., Walters G. Arginine infusion blocks the action of parathyroid hormone but not arginine vasopressin on the renal tubule in man. J Endocrinol. 1986 Dec;111(3):501–506. doi: 10.1677/joe.0.1110501. [DOI] [PubMed] [Google Scholar]
  19. Schou M., Thomsen K., Vestergaard P. The renal lithium clearance and its correlations with other biological variables: observations in a large group of physically healthy persons. Clin Nephrol. 1986 Apr;25(4):207–211. [PubMed] [Google Scholar]
  20. Schuster V. L., Kokko J. P., Jacobson H. R. Angiotensin II directly stimulates sodium transport in rabbit proximal convoluted tubules. J Clin Invest. 1984 Feb;73(2):507–515. doi: 10.1172/JCI111237. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Shopsin B., Sathananthan G., Gershon S. Plasma renin response to lithium in psychiatric patients. Clin Pharmacol Ther. 1973 Jul-Aug;14(4):561–564. doi: 10.1002/cpt1973144part1561. [DOI] [PubMed] [Google Scholar]
  22. Singer I. Lithium and the kidney. Kidney Int. 1981 Feb;19(2):374–387. doi: 10.1038/ki.1981.28. [DOI] [PubMed] [Google Scholar]
  23. Stewart P. M., Grieve J., Nairn I. M., Padfield P. L., Edwards C. R. Lithium inhibits the action of fludrocortisone on the kidney. Clin Endocrinol (Oxf) 1987 Jul;27(1):63–68. doi: 10.1111/j.1365-2265.1987.tb00839.x. [DOI] [PubMed] [Google Scholar]
  24. Sutherland E. W. On the biological role of cyclic AMP. JAMA. 1970 Nov 16;214(7):1281–1288. [PubMed] [Google Scholar]
  25. Thompson L., Morgan T., Carney S. Lithium administration and urinary electrolyte excretion in the rat. Miner Electrolyte Metab. 1984;10(2):122–126. [PubMed] [Google Scholar]
  26. Thomsen K., Leyssac P. P. Acute effects of various diuretics on lithium clearance. Studies in rats on medium and low sodium diet. Ren Physiol. 1986;9(1-2):1–8. [PubMed] [Google Scholar]
  27. Thomsen K. Lithium clearance: a new method for determining proximal and distal tubular reabsorption of sodium and water. Nephron. 1984;37(4):217–223. doi: 10.1159/000183252. [DOI] [PubMed] [Google Scholar]
  28. Vlachoyannis J., Weismüller G., Schoeppe W. Effects of dopamine on kidney function and on the adenyl cyclase phosphodiesterase system in man. Eur J Clin Invest. 1976 Mar 31;6(2):131–137. doi: 10.1111/j.1365-2362.1976.tb00503.x. [DOI] [PubMed] [Google Scholar]
  29. Waller D. G., Albano J. D., Millar J. G., Polak A. Cyclic AMP responses to parathyroid hormone and glucagon during lithium treatment. Clin Sci (Lond) 1984 May;66(5):557–559. doi: 10.1042/cs0660557. [DOI] [PubMed] [Google Scholar]
  30. Waller D. G., Albano J. D., Millar J. G., Polak A. Impairment of cyclic AMP response to bovine parathyroid hormone in patients on chronic lithium therapy with diminished renal urine-concentrating ability. Clin Sci (Lond) 1983 Jun;64(6):623–627. doi: 10.1042/cs0640623. [DOI] [PubMed] [Google Scholar]
  31. Weinman E. J., Shenolikar S., Kahn A. M. cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. Am J Physiol. 1987 Jan;252(1 Pt 2):F19–F25. doi: 10.1152/ajprenal.1987.252.1.F19. [DOI] [PubMed] [Google Scholar]
  32. Worth D. P., Harvey J. N., Brown J., Lee M. R. gamma-L-Glutamyl-L-dopa is a dopamine pro-drug, relatively specific for the kidney in normal subjects. Clin Sci (Lond) 1985 Aug;69(2):207–214. doi: 10.1042/cs0690207. [DOI] [PubMed] [Google Scholar]

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