Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Jun;25(6):751–754. doi: 10.1111/j.1365-2125.1988.tb05262.x

The effect of nisoldipine on whole blood platelet aggregation in patients with Raynaud's phenomenon.

J L Francis 1, O S Roath 1, V F Challenor 1, D G Waller 1
PMCID: PMC1386453  PMID: 3203045

Abstract

1. Whole blood platelet aggregation was measured by electrical impedance in 28 controls and 28 patients with primary Raynaud's phenomenon. 2. The patients were entered into a double-blind, placebo-controlled cross-over trial of the calcium antagonist nisoldipine, in which they received, in random order, three, 4 week treatments with placebo and nisoldipine (5 and 10 mg day-1). 3. Platelet aggregation responses to two concentrations (5.0 and 0.5 micrograms ml-1) of collagen were determined before treatment and at the end of each treatment phase. 4. There were no differences in aggregation response to either collagen concentration between controls and patients with primary Raynaud's phenomenon, or between placebo and active treatment phases. 5. These data do not support the suggestion that nisoldipine has a significant anti-platelet effect.

Full text

PDF
751

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Challenor V. F., Waller D. G., Francis D. A., Francis J. L., Mani R., Roath S. Nisoldipine in primary Raynaud's phenomenon. Eur J Clin Pharmacol. 1987;33(1):27–30. doi: 10.1007/BF00610375. [DOI] [PubMed] [Google Scholar]
  2. Dale J., Landmark K. H., Myhre E. The effects of nifedipine, a calcium antagonist, on platelet function. Am Heart J. 1983 Jan;105(1):103–105. doi: 10.1016/0002-8703(83)90285-5. [DOI] [PubMed] [Google Scholar]
  3. Francis J. L. Improved assessment of impedance aggregometry using a microcomputer. Thromb Res. 1987 Mar 15;45(6):851–855. doi: 10.1016/0049-3848(87)90095-8. [DOI] [PubMed] [Google Scholar]
  4. Han P., Boatwright C., Ardlie N. G. Effect of the calcium-entry blocking agent nifedipine on activation of human platelets and comparison with verapamil. Thromb Haemost. 1983 Aug 30;50(2):513–517. [PubMed] [Google Scholar]
  5. Han P., Boatwright C., Ardlie N. G. Inhibition of platelet function of antiarrhythmic drugs, verapamil and disopyramide. Thromb Haemost. 1982 Apr 30;47(2):150–153. [PubMed] [Google Scholar]
  6. Hutton R. A., Mikhailidis D. P., Bernstein R. M., Jeremy J. Y., Hughes G. R., Dandona P. Assessment of platelet function in patients with Raynaud's syndrome. J Clin Pathol. 1984 Feb;37(2):182–187. doi: 10.1136/jcp.37.2.182. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Ikeda Y., Kikuchi M., Toyama K., Watanabe K., Ando Y. Inhibition of human platelet functions by verapamil. Thromb Haemost. 1981 Apr 30;45(2):158–161. [PubMed] [Google Scholar]
  8. Ingerman-Wojenski C. M., Smith J. B., Silver M. J. Difficulty in detecting inhibition of platelet aggregation by the impedance method. Thromb Res. 1982 Nov 1;28(3):427–432. doi: 10.1016/0049-3848(82)90124-4. [DOI] [PubMed] [Google Scholar]
  9. Jeremy J. Y., Barradas M. A., Mikhailidis D. P., Dandona P. An investigation into the effects of nifedipine and nimodipine on platelet function and vascular prostacyclin synthesis. Drugs Exp Clin Res. 1985;11(9):645–651. [PubMed] [Google Scholar]
  10. Johnsson H. Effects of nifedipine (Adalat) on platelet function in vitro and in vivo. 1981 Feb 15-Mar 1Thromb Res. 21(4-5):523–528. doi: 10.1016/0049-3848(81)90155-9. [DOI] [PubMed] [Google Scholar]
  11. Jones C. R., Pasanisi F., Elliott H. L., Reid J. L. Effects of verapamil and nisoldipine on human platelets: in vivo and in vitro studies. Br J Clin Pharmacol. 1985 Sep;20(3):191–196. doi: 10.1111/j.1365-2125.1985.tb05060.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mackie I. J., Jones R., Machin S. J. Platelet impedance aggregation in whole blood and its inhibition by antiplatelet drugs. J Clin Pathol. 1984 Aug;37(8):874–878. doi: 10.1136/jcp.37.8.874. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Murphy M. B., Orchard M. A., Conway E. L., Barrow S. E. The effects of nifedipine on platelet aggregation and plasma 6-keto-PGF1 alpha, and its interaction with indomethacin. Eur J Clin Pharmacol. 1985;29(4):413–416. doi: 10.1007/BF00613454. [DOI] [PubMed] [Google Scholar]
  14. Nayler W. G., Dillon J. S. Calcium antagonists and their mode of action: an historical overview. Br J Clin Pharmacol. 1986;21 (Suppl 2):97S–107S. doi: 10.1111/j.1365-2125.1986.tb02859.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Riess H., Braun G., Brehm G., Hiller E. Critical evaluation of platelet aggregation in whole human blood. Am J Clin Pathol. 1986 Jan;85(1):50–56. doi: 10.1093/ajcp/85.1.50. [DOI] [PubMed] [Google Scholar]
  16. Sauza J., Kraus A., González-Amaro R., Alarcón-Segovia D. Effect of the calcium channel blocker nifedipine on Raynaud's phenomenon. A controlled double blind trial. J Rheumatol. 1984 Jun;11(3):362–364. [PubMed] [Google Scholar]
  17. Schrör K., Latta G., Darius H., Klaus W., Ziegler R. Hemmung der Plättchenaggregation und Thromboxanbildung durch den Calcium-Antagonisten Nisoldipin nach einer oralen Einmaldosis von 10 mg. Eine Doppelblind-Crossover-Studie bei gesunden Probanden. Klin Wochenschr. 1985 Jan 2;63(1):16–19. [PubMed] [Google Scholar]
  18. Sorkin E. M., Clissold S. P., Brogden R. N. Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders. Drugs. 1985 Sep;30(3):182–274. doi: 10.2165/00003495-198530030-00002. [DOI] [PubMed] [Google Scholar]
  19. Takahara K., Kuroiwa A., Matsushima T., Nakashima Y., Takasugi M. Effects of nifedipine on platelet function. Am Heart J. 1985 Jan;109(1):4–8. doi: 10.1016/0002-8703(85)90408-9. [DOI] [PubMed] [Google Scholar]
  20. Waller D. G., Challenor V. F., Francis D. A., Roath O. S. Clinical and rheological effects of nifedipine in Raynaud's phenomenon. Br J Clin Pharmacol. 1986 Oct;22(4):449–454. doi: 10.1111/j.1365-2125.1986.tb02916.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Zahavi J., Hamilton W. A., O'Reilly M. J., Leyton J., Cotton L. T., Kakkar V. V. Plasma exchange and platelet function in Raynaud's phenomenon. Thromb Res. 1980 Jul 1;19(1-2):85–93. doi: 10.1016/0049-3848(80)90406-5. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES