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. 1988 Feb;25(2):187–193. doi: 10.1111/j.1365-2125.1988.tb03290.x

Acute inotropic effects of intravenous nifedipine and its vehicle compared with saline: a double-blind study of systolic time intervals in normal subjects.

T J Walley 1, A M Heagerty 1, K L Woods 1, R F Bing 1, J E Pohl 1, D B Barnett 1
PMCID: PMC1386473  PMID: 3358882

Abstract

1. The inotropic effects of intravenous nifedipine and its vehicle were studied noninvasively in a double-blind placebo controlled crossover fashion using systolic time intervals in 12 normal subjects. 2. Nifedipine caused vasodilation, a fall in systolic and diastolic blood pressure, and increased heart rate. The vehicle alone caused vasodilation and decreased systolic blood pressure, without a change in heart rate. 3. Nifedipine increased left ventricular ejection time (LVET) and decreased pre-ejection period (PEP) and the ratio PEP/LVET, whereas the vehicle alone had the opposite effect. Neither treatment affected the total duration of electromechanical systole. 4. These results suggest that the vehicle has a negative inotropic effect, which is overcome by the indirect positive inotropic effect of nifedipine when they are administered together systemically.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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