Skip to main content
NCBI home page
British Journal of Clinical Pharmacology logoLink to British Journal of Clinical Pharmacology
. 1988 Jul;26(1):73–77. doi: 10.1111/j.1365-2125.1988.tb03366.x

Circadian variation in theophylline absorption during chronic dosing with a slow release theophylline preparation and the effect of clock time of dosing.

S H Jackson 1, A Johnston 1, R Woollard 1, S M Abrams 1, P Turner 1
PMCID: PMC1386502  PMID: 3203064

Abstract

1. Eight volunteers were given seven doses of 200 mg of slow release theophylline at either 11.00 h and 23.00 h (regimen 1) or 17.00 h and 05.00 h (regimen 2). At the time of the sixth dose (60 h) hourly blood sampling was started and continued for 24 h. After at least 1 week volunteers crossed over to the other regimen. 2. Volunteers retired to bed at 23.00 h and arose after the 07.00 h sample during both regimens. 3. During regimen 1 there was a marked rise in mean tmax from 3.3 h after dosing at 11.00 h to 9.3 h after dosing at 23.00 h (P less than 0.001). There was also a fall in AUC(0,12) from 89.9 mg l-1 h after dosing at 11.00 h to 79.0 mg l-1 h after dosing at 23.00 h. There was no difference in mean Cmax values. 4. During regimen 2 these circadian changes were abolished with mean values after both dosing times lying between those observed during regimen 1. 5. A marked delay in absorption occurs at night and cannot be explained by food intake.

Full text

PDF
73

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Chang J., Gotcher S., Gushaw J. B. Homogeneous enzyme immunoassay for theophylline in serum and plasma. Clin Chem. 1982 Feb;28(2):361–367. [PubMed] [Google Scholar]
  2. Coulthard K. P., Birkett D. J., Lines D. R., Grgurinovich N., Grygiel J. J. Bioavailability and diurnal variation in absorption of sustained release theophylline in asthmatic children. Eur J Clin Pharmacol. 1983;25(5):667–672. doi: 10.1007/BF00542356. [DOI] [PubMed] [Google Scholar]
  3. Halberg F., Simpson H. Circadian acrophases of human 17-hydroxycorticosteroid excretion referred to midsleep rather than midnight. Hum Biol. 1967 Dec;39(4):405–413. [PubMed] [Google Scholar]
  4. Jackson S. H., Shah K., Turner P. Methods of comparing pharmacokinetics of slow release preparations: a comparison of "Theo-Dur" and "Phyllocontin" in patients with asthma. Eur J Clin Pharmacol. 1986;30(3):313–317. doi: 10.1007/BF00541535. [DOI] [PubMed] [Google Scholar]
  5. Jackson S. H., Wiffen J. K., Smythe M. M., Johnston A. Is circadian variation in theophylline trough serum concentrations determined by time of dosing? Br J Clin Pharmacol. 1984 Jun;17(6):777–779. doi: 10.1111/j.1365-2125.1984.tb02419.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Karim A., Burns T., Wearley L., Streicher J., Palmer M. Food-induced changes in theophylline absorption from controlled-release formulations. Part I. Substantial increased and decreased absorption with Uniphyl tablets and Theo-Dur Sprinkle. Clin Pharmacol Ther. 1985 Jul;38(1):77–83. doi: 10.1038/clpt.1985.138. [DOI] [PubMed] [Google Scholar]
  7. Leeds N. H., Gal P., Purohit A. A., Walter J. B. Effect of food on the bioavailability and pattern of release of a sustained-release theophylline tablet. J Clin Pharmacol. 1982 Apr;22(4):196–200. doi: 10.1002/j.1552-4604.1982.tb02162.x. [DOI] [PubMed] [Google Scholar]
  8. Lesko L. J., Brousseau D., Canada A. T., Eastwood G. Temporal variations in trough serum theophylline concentrations at steady state. J Pharm Sci. 1980 Mar;69(3):358–359. doi: 10.1002/jps.2600690332. [DOI] [PubMed] [Google Scholar]
  9. Nakano S., Hollister L. E. Chronopharmacology of amitriptyline. Clin Pharmacol Ther. 1983 Apr;33(4):453–459. doi: 10.1038/clpt.1983.61. [DOI] [PubMed] [Google Scholar]
  10. Primrose W. R. Asthma at night. Lancet. 1983 Apr 23;1(8330):927–927. doi: 10.1016/s0140-6736(83)91351-x. [DOI] [PubMed] [Google Scholar]
  11. Scott P. H., Kramer W. G., Smolensky M. H., Harrist R. Circadian rhythms in theophylline pharmacokinetics and pharmacodynamics in asthmatic children. Br J Clin Pract Suppl. 1984;35:57–63. [PubMed] [Google Scholar]
  12. Sips A. P., Edelbroek P. M., Kulstad S., de Wolff F. A., Dijkman J. H. Food does not effect in bioavailability of theophylline from Theolin Retard. Eur J Clin Pharmacol. 1984;26(3):405–407. doi: 10.1007/BF00548776. [DOI] [PubMed] [Google Scholar]
  13. Smith R. B., Kroboth P. D., Phillips J. P. Temporal variation in triazolam pharmacokinetics and pharmacodynamics after oral administration. J Clin Pharmacol. 1986 Feb;26(2):120–124. doi: 10.1002/j.1552-4604.1986.tb02919.x. [DOI] [PubMed] [Google Scholar]
  14. Steffensen G., Pedersen S. Food induced changes in theophylline absorption from a once-a-day theophylline product. Br J Clin Pharmacol. 1986 Nov;22(5):571–577. doi: 10.1111/j.1365-2125.1986.tb02937.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Taylor D. R., Duffin D., Kinney C. D., McDevitt D. G. Investigation of diurnal changes in the disposition of theophylline. Br J Clin Pharmacol. 1983 Oct;16(4):413–416. doi: 10.1111/j.1365-2125.1983.tb02186.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Uematsu T., Follath F., Vozeh S. Circadian changes in the absorption and elimination of theophylline in patients with bronchial obstruction. Eur J Clin Pharmacol. 1986;30(3):309–312. doi: 10.1007/BF00541534. [DOI] [PubMed] [Google Scholar]
  17. Warren J. B., Cuss F., Barnes P. J. Posture and theophylline kinetics. Br J Clin Pharmacol. 1985 May;19(5):707–709. doi: 10.1111/j.1365-2125.1985.tb02701.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Warren J. Theophylline concentrations and posture. Lancet. 1983 Oct 8;2(8354):850–850. doi: 10.1016/s0140-6736(83)90764-x. [DOI] [PubMed] [Google Scholar]

Articles from British Journal of Clinical Pharmacology are provided here courtesy of British Pharmacological Society

RESOURCES