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. 1988 Jul;26(1):92–95. doi: 10.1111/j.1365-2125.1988.tb03369.x

Penetration of nadolol into aqueous humour after a single oral dose.

T H Tiong 1, S O Hung 1, M S Perelman 1
PMCID: PMC1386505  PMID: 3203065

Abstract

Nadolol 20 mg was administered orally as a single-blind, single dose to nine patients about to undergo cataract extraction. Intraocular pressures fell by a mean of 24% 3 h after administration. During the operation, aqueous humour and serum samples were taken for measurement of nadolol concentrations. Aqueous nadolol concentrations ranged from 3.8 to 13.4 ng ml-1, and correlated with the serum drug concentrations (r = 0.84). The fall in intraocular pressure did not correlate with either the aqueous humour or plasma concentrations of nadolol.

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Selected References

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